p-Toluoyl chloride

Synonym(s):4-Methylbenzoyl chloride

CAS NO.：874-60-2
Empirical Formula: C8H7ClO
Molecular Weight: 154.59
MDL number: MFCD00000696
EINECS: 212-864-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-14 20:10:21

What is p-Toluoyl chloride?

Chemical properties

CLEAR COLOURLESS TO SLIGHTLY BROWNISH LIQUID

The Uses of p-Toluoyl chloride

p-Toluoyl chloride was used to prepare antigen, Tolyl-amido-human serum albumin

The Uses of p-Toluoyl chloride

Intermediates of Liquid Crystals

The Uses of p-Toluoyl chloride

p-Toluoyl chloride was used to prepare antigen, Tolyl-amido-human serum albumin. It is used as a reagent to synthesize (+)-Yashabushitriol, derivatives of Desloratadine.

General Description

p-Toluoyl chloride causes the benzoylation of toluene using triflic acid funtionalized mesoporous Zr-TMS catalysts. It causes1,9-diacylation of a dipyrromethane using the hindered Grignard reagent 2,6-dimethylphenylmagnesium bromide.

Properties of p-Toluoyl chloride

Melting point:	-4--2 °C (lit.)
Boiling point:	225-227 °C (lit.) 95-96 °C/10 mmHg (lit.)
Density	1.169 g/mL at 25 °C (lit.)
vapor density	5.33 (vs air)
vapor pressure	0.55 mm Hg ( 20 °C)
refractive index	n20/D 1.553(lit.)
Flash point:	180 °F
storage temp.	Store below +30°C.
form	Liquid
color	Clear colorless to slightly brown
Specific Gravity	1.169
PH	1 (H2O, 20℃)
explosive limit	1.6%, 117°F
Water Solubility	Reacts with water alcohol.
Sensitive	Moisture Sensitive
BRN	471492
CAS DataBase Reference	874-60-2(CAS DataBase Reference)
NIST Chemistry Reference	4-Methylbenzoic acid chloride(874-60-2)
EPA Substance Registry System	Benzoyl chloride, 4-methyl- (874-60-2)

Safety information for p-Toluoyl chloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.