Oxobutanedioic acid
Synonym(s):2-Oxosuccinic acid;Ketosuccinic acid;OAA;Oxalacetic acid;Oxobutanedioic acid
- CAS NO.:328-42-7
- Empirical Formula: C4H4O5
- Molecular Weight: 132.07
- MDL number: MFCD00002592
- EINECS: 206-329-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 13:37:16
What is Oxobutanedioic acid?
Description
Oxaloacetic acid is an α-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate. Oxaloacetate reacts with acetyl-coenzyme A (acetyl-CoA; ) and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step. It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate. It can be converted to aspartate via addition of an amino group from glutamate. Oxaloacetate (30 μmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.
Chemical properties
off-white crystals
The Uses of Oxobutanedioic acid
A four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase.
The Uses of Oxobutanedioic acid
Oxaloacetic acid is a substrate for malate dehydrogenase and oxaloacetate decarboxylase. It is an inhibitor of succinic dehydrogenase. It is an intermediate in the citric acid cycle and glucogenesis.
The Uses of Oxobutanedioic acid
Use as a TCA (Krebs cycle) intermediate supplement in hybridoma cell culture applications. Enhances hybridoma growth and productivity.
What are the applications of Application
Oxaloacetic Acid is a malate dehydrogenase and oxaloacetate decarboxylase substrate
Definition
ChEBI: An oxodicarboxylic acid that is succinic acid bearing a single oxo group.
General Description
Oxaloacetic acid is a dicarboxylic acid. It is an intermediate in the citric acid cycle. It is highly soluble in water and is present ubiquitously. It is produced in the mitochondria by the action of pyruvate carboxylase on pyruvate. Breakdown products of oxaloacetate includes malate, pyruvate and aspartic acid.
Flammability and Explosibility
Not classified
Biological Activity
Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid) is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalysed by citrate synthase. It is also involved in gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Oxaloacetate is also a potent inhibitor of Complex II.
Biochem/physiol Actions
Oxaloacetic acid being an intermediate in the tri carboxylic cycle is central to metabolism. It is part of gluconeogenesis pathway. Mutation in pyruvate carboxylase leads to decreased production of oxaloacetate. It inhibits succinate dehydrogenase and is a key regulator of mitochondrial metabolism.
Purification Methods
Crystallise it from boiling EtOAc, or from hot Me2CO/hot *C6H6. [Beilstein 3 IV 1808.]
Properties of Oxobutanedioic acid
Melting point: | 161 °C (dec.)(lit.) |
Boiling point: | 163.94°C (rough estimate) |
Density | 1.3067 (rough estimate) |
vapor pressure | 0.003Pa at 20℃ |
refractive index | 1.4000 (estimate) |
Flash point: | 88°C |
storage temp. | -20°C |
solubility | H2O: 100 mg/mL |
form | powder |
pka | 2.22(at 25℃) |
color | White to off-white |
PH | 3.05(1 mM solution);2.29(10 mM solution);1.68(100 mM solution) |
Water Solubility | soluble |
Merck | 14,6909 |
BRN | 1705475 |
Stability: | Stable. Incompatible with strong oxidizing agents. Keep refrigerated. |
CAS DataBase Reference | 328-42-7(CAS DataBase Reference) |
NIST Chemistry Reference | Oxalacetic acid(328-42-7) |
EPA Substance Registry System | Oxalacetic acetic (328-42-7) |
Safety information for Oxobutanedioic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Oxobutanedioic acid
Oxobutanedioic acid manufacturer
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1,1’-CARBONYLDIIMIDAZOLE DIETHYL AMINOMALONATE HYDROCHLORIDE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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