Optovin

CAS NO.：348575-88-2
Empirical Formula: C15H13N3OS2
Molecular Weight: 315.41
MDL number: MFCD02219276
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is Optovin?

Description

Optovin (348575-88-2) is a reversible photoactive TRPA1 activator. Optovin stimulates human TRPA1 channels and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50?= 2 μM) and mice,?in vivo. Photodetection is performed by sensory neurons expressing the TRPA1 cation channel which is activated via structure-dependent photochemical reactions with redox-sensitive cysteine residues.1

The Uses of Optovin

Optovin activates human TRPA1 via structure-dependent photochemistry.

Definition

ChEBI: Optovin is a member of the class of thiazolidinone that is rhodanine in which the two methylene hydrogens have been replaced by a 2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl]methylidene group. A TRPA1 ligand that can be reversibly photoactivated. It has a role as a TRPA1 channel agonist. It is a member of pyrroles, a member of pyridines, an olefinic compound and a thiazolidinone. It is functionally related to a rhodanine.

storage

Store at +4°C

References

1) Kokel?et al. (2013),?Photochemical activation of TRPA1 channels in neurons and animals; Nat. Chem. Biol.,?9?257

Properties of Optovin

Density	1.38±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Soluble in DMSO (up to 30 mg/ml)
form	solid
pka	7.65±0.50(Predicted)
color	Tan
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety information for Optovin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.