OPIPRAMOL DIHYDROCHLORIDE
- CAS NO.：909-39-7
- Empirical Formula: C23H31Cl2N3O
- Molecular Weight: 436.41774
- MDL number: MFCD00941483
- EINECS: 213-000-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is OPIPRAMOL DIHYDROCHLORIDE?
Originator
Insidon,Geigy,W. Germany,1962
The Uses of OPIPRAMOL DIHYDROCHLORIDE
antidepressant, antipsychotic;'sigma antagonist
Manufacturing Process
A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C.
Therapeutic Function
Antidepressant, Antipsychotic
Properties of OPIPRAMOL DIHYDROCHLORIDE
| Melting point: | 210° (FR M209); mp 228-230° (DE 1133729) |
| solubility | H2O: ~24 mg/mL |
| form | solid |
| color | yellow |
Safety information for OPIPRAMOL DIHYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for OPIPRAMOL DIHYDROCHLORIDE
OPIPRAMOL DIHYDROCHLORIDE manufacturer
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