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HomeProduct name listOPIPRAMOL DIHYDROCHLORIDE

OPIPRAMOL DIHYDROCHLORIDE

  • CAS NO.:909-39-7
  • Empirical Formula: C23H31Cl2N3O
  • Molecular Weight: 436.41774
  • MDL number: MFCD00941483
  • EINECS: 213-000-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
OPIPRAMOL DIHYDROCHLORIDE Structural

What is OPIPRAMOL DIHYDROCHLORIDE?

Originator

Insidon,Geigy,W. Germany,1962

The Uses of OPIPRAMOL DIHYDROCHLORIDE

antidepressant, antipsychotic;'sigma antagonist

Manufacturing Process

A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C.

Therapeutic Function

Antidepressant, Antipsychotic

Properties of OPIPRAMOL DIHYDROCHLORIDE

Melting point: 210° (FR M209); mp 228-230° (DE 1133729)
solubility  H2O: ~24 mg/mL
form  solid
color  yellow

Safety information for OPIPRAMOL DIHYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Environment
GHS09
GHS Hazard Statements H302:Acute toxicity,oral
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P273:Avoid release to the environment.
P391:Collect spillage. Hazardous to the aquatic environment
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for OPIPRAMOL DIHYDROCHLORIDE

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