OPIPRAMOL

Synonym(s):4-[3-(5H-Dibenz[b,f]azepin-5-yl)-propyl]-1-piperazineethanol;NSC 169867

CAS NO.：315-72-0
Empirical Formula: C23H29N3O
Molecular Weight: 363.5
MDL number: MFCD00865455
EINECS: 206-254-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is OPIPRAMOL?

Chemical properties

Crystalline Solid

Originator

Insidon,Geigy,W. Germany,1962

The Uses of OPIPRAMOL

Antidepressant; antipsychotic

What are the applications of Application

Opipramol is A tricyclic biochemical used for research purposes

Definition

ChEBI: 2-[4-[3-(11-benzo[b][1]benzazepinyl)propyl]-1-piperazinyl]ethanol is a dibenzoazepine.

Manufacturing Process

A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C.

Therapeutic Function

Antidepressant, Antipsychotic

Properties of OPIPRAMOL

Melting point:	100-1010C
Boiling point:	494.88°C (rough estimate)
Density	1.0920 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	-20°C Freezer
solubility	Acetonitrile: slightly soluble; Chloroform: slightly soluble; Methanol: slightly soluble
pka	pKa 8(H2O,t =25,I=0.01(NaCl)) (Uncertain)
form	neat
form	Solid
color	Light yellow to yellow
BRN	627076

Safety information for OPIPRAMOL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P501:Dispose of contents/container to..…