OPIPRAMOL
Synonym(s):4-[3-(5H-Dibenz[b,f]azepin-5-yl)-propyl]-1-piperazineethanol;NSC 169867
- CAS NO.：315-72-0
- Empirical Formula: C23H29N3O
- Molecular Weight: 363.5
- MDL number: MFCD00865455
- EINECS: 206-254-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:14
What is OPIPRAMOL?
Chemical properties
Crystalline Solid
Originator
Insidon,Geigy,W. Germany,1962
The Uses of OPIPRAMOL
Antidepressant; antipsychotic
What are the applications of Application
Opipramol is A tricyclic biochemical used for research purposes
Definition
ChEBI: 2-[4-[3-(11-benzo[b][1]benzazepinyl)propyl]-1-piperazinyl]ethanol is a dibenzoazepine.
Manufacturing Process
A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C.
Therapeutic Function
Antidepressant, Antipsychotic
Properties of OPIPRAMOL
| Melting point: | 100-1010C |
| Boiling point: | 494.88°C (rough estimate) |
| Density | 1.0920 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Acetonitrile: slightly soluble; Chloroform: slightly soluble; Methanol: slightly soluble |
| pka | pKa 8(H2O,t =25,I=0.01(NaCl)) (Uncertain) |
| form | neat |
| form | Solid |
| color | Light yellow to yellow |
| BRN | 627076 |
Safety information for OPIPRAMOL
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P501:Dispose of contents/container to..… |
Computed Descriptors for OPIPRAMOL
New Products
2,2-diethoxyethanethioamide Tubulysin G Tubulysin I (S)-(+)-3-HYDROXYTETRAHYDROFURAN 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID Cyclobutanamine, 3,3-difluoro- (9CI) 4,4-DIFLUOROPIPERIDINE 4-(Benzyloxy)-3-bromophenylacetic Acid 2,2-Difluoropropylamine hydrochloride (S)-4-(azidomethyl) -3-(3-fluoro-4- thiomorpholino phenyl) oxazolidin-2-one 7-chloro-1- (2-methyl-4- nitrobenzoyl)-3,4- dihydro-1H-benzo[b] azepin-5(2H)-one (2,3-Dihydro- benzofuran-5-yl)- ethanol 2-Bromo-6- nitroanisole (+/-)-6-Acetylamino-2- amino-4, 5, 6, 7-tetrahydro Benzo thiazole 2,3-dichloro-6- nitrobenzonitrile 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile Methyl (2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoate (R)-methyl 2-formamido-3-(tritylthio)propanoate (R)-methyl 2-isocyano-3-(tritylthio)propanoate Salbutamol EP Impurity K / Salbutamol BP Impurity K Sertraline EP Impurity B / Sertraline BP Impurity B / 3,4-Dideschloro Sertraline HCl (USP) / cis-3,4-Dideschloro Sertraline HCl / Sertraline Phenyl Impurity HALOPERIDOL DECANOATE EP IMPURITY J | HALOPERIDOL UNDECANOATERelated products of tetrahydrofuran
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