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HomeProduct name listOphthazin

Ophthazin

  • CAS NO.:484-23-1
  • Empirical Formula: C8H10N6
  • Molecular Weight: 190.21
  • MDL number: MFCD01250766
  • EINECS: 207-605-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:39
Ophthazin Structural

What is Ophthazin?

Originator

Nepresol,Novartis

The Uses of Ophthazin

Ophthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.

Background

Dihydralazine is under investigation in clinical trial NCT00311974 (The Effect of Dihydralazine on Kidney Function and Hormones in Healthy Individuals).

Definition

ChEBI: Dihydralazine is a member of phthalazines.

Manufacturing Process

115 parts of hydrazine hydrate in 80 parts 50% acetic acid were added to 128 parts of phthalic acid dinitrile in 250 parts dioxane. The mixture was heated at the temperature 95°C for 3 hours with stirring. After 20 minutes the crystallization and discharging of NH3 began. The orange needles were filtered off after cooling. The product was washed with dioxane and ethanol and recrystallized from 3000 parts of water to yield 110 parts colorless needles of 1,4-dihydrazino-phthalazine; MP: 191°-193°C (decomp.). The crystals were getting a little orange color by standing because of a reaction with an air oxygen.

Therapeutic Function

Antihypertensive

Safety Profile

Poison by intravenous route. Anexperimental teratogen. When heated to decomposition itemits toxic fumes of NOx.

Metabolism

Not Available

Properties of Ophthazin

Melting point: 180°C (rough estimate)
Boiling point: 315.71°C (rough estimate)
Density  1.3243 (rough estimate)
refractive index  1.8100 (estimate)
pka 3?+-.0.20(Predicted)
color  Orange crystals from H2O

Safety information for Ophthazin

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P310:Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Ophthazin

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