Ophthazin
- CAS NO.:484-23-1
- Empirical Formula: C8H10N6
- Molecular Weight: 190.21
- MDL number: MFCD01250766
- EINECS: 207-605-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:39
What is Ophthazin?
Originator
Nepresol,Novartis
The Uses of Ophthazin
Ophthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.
Background
Dihydralazine is under investigation in clinical trial NCT00311974 (The Effect of Dihydralazine on Kidney Function and Hormones in Healthy Individuals).
Definition
ChEBI: Dihydralazine is a member of phthalazines.
Manufacturing Process
115 parts of hydrazine hydrate in 80 parts 50% acetic acid were added to 128 parts of phthalic acid dinitrile in 250 parts dioxane. The mixture was heated at the temperature 95°C for 3 hours with stirring. After 20 minutes the crystallization and discharging of NH3 began. The orange needles were filtered off after cooling. The product was washed with dioxane and ethanol and recrystallized from 3000 parts of water to yield 110 parts colorless needles of 1,4-dihydrazino-phthalazine; MP: 191°-193°C (decomp.). The crystals were getting a little orange color by standing because of a reaction with an air oxygen.
Therapeutic Function
Antihypertensive
Safety Profile
Poison by intravenous route. Anexperimental teratogen. When heated to decomposition itemits toxic fumes of NOx.
Metabolism
Not Available
Properties of Ophthazin
Melting point: | 180°C (rough estimate) |
Boiling point: | 315.71°C (rough estimate) |
Density | 1.3243 (rough estimate) |
refractive index | 1.8100 (estimate) |
pka | 3?+-.0.20(Predicted) |
color | Orange crystals from H2O |
Safety information for Ophthazin
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Ophthazin
New Products
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