Olsalazine sodium
Synonym(s):4,4′-Dihydroxyazobenzene-3,3′-dicarboxylic acid disodium salt;5,5′-Azobis(salicylic acid, sodium salt);Mordant Yellow 5
- CAS NO.:6054-98-4
- Empirical Formula: C14H11N2NaO6
- Molecular Weight: 326.24
- MDL number: MFCD00013300
- EINECS: 227-975-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is Olsalazine sodium?
Chemical properties
Yellow Crystalline Powder
The Uses of Olsalazine sodium
Dimer of Mesalamine. It is an anti-inflammatorydrug used in the treatment of inflammatory bowel disease and ulcerative colitis
The Uses of Olsalazine sodium
Dimer of Mesalazine (M258100), an anti-inflammatory drug used in the treatment of inflammatory bowel disease and ulcerative colitis.
The Uses of Olsalazine sodium
Mordant dye for wool.
What are the applications of Application
Olsalazine Sodium is an anti-inflammatory agent
Definition
ChEBI: An organic sodium salt that is the disodium salt of 3,3'-azobis(6-hydroxybenzoic acid) (olsalazine). Effective in the treatment of inflammatory bowel disease and ulcerative colitis. Mechanism of action unknown, but appears to be topical
Preparation
5-Amino-2-chlorobenzoic acid diazotization, coupled with 2-Hydroxybenzoic acid, and then in a certain pressure and contains trace copper powder or Cupric oxide of Sodium hydroxide solution common heating (130 ~ 150 ℃).
brand name
Dipentum (UCB).
Clinical Use
Induction and maintenance of remission in ulcerative colitis
Metabolism
Olsalazine is broken down by the colonic bacterial flora
into 2 molecules of 5-aminosalicylic acid (mesalazine).
The small amounts (1-2% of the dose or less) of intact
olsalazine that are absorbed are excreted mainly in urine.
Approximately 0.1% of an oral dose of olsalazine
is hepatically metabolised to olsalazine-O-sulfate
(olsalazine-S), which has a half-life of 7 days.
Properties and Applications
deep green light yellow. Soluble in water for green light yellow, moderate soluble in Etanol for green yellow. In concentrated sulfuric acid for yellow orange, dilution after light yellow, In concentrated nitric acid to red. Dye aqueous solution to join concentrated hydrochloric acid color greatly shallow for yellow; Join concentrated Sodium hydroxide solution for golden orange.
Standard | Ironing Fastness | Light Fastness | Fulling | Persperation Fastness | Soaping | Water | |
Alkali | Acid | ||||||
ISO | 4-5 | 6 | 4-5 | 2-3 | 4-5 | 5 | 5 |
AATCC | 5 | 6-7 | 4 | 5 | 5 | 5 |
Properties of Olsalazine sodium
Melting point: | 240 °C |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | Sparingly soluble in water, soluble in dimethyl sulfoxide, very slightly soluble in methanol. |
form | neat |
form | Solid |
color | Light Yellow to Yellow |
CAS DataBase Reference | 6054-98-4(CAS DataBase Reference) |
EPA Substance Registry System | Benzoic acid, 3,3'-azobis[6-hydroxy-, disodium salt (6054-98-4) |
Safety information for Olsalazine sodium
Computed Descriptors for Olsalazine sodium
Abamectin manufacturer
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