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HomeProduct name listOlsalazine sodium

Olsalazine sodium

Synonym(s):4,4′-Dihydroxyazobenzene-3,3′-dicarboxylic acid disodium salt;5,5′-Azobis(salicylic acid, sodium salt);Mordant Yellow 5

  • CAS NO.:6054-98-4
  • Empirical Formula: C14H11N2NaO6
  • Molecular Weight: 326.24
  • MDL number: MFCD00013300
  • EINECS: 227-975-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
Olsalazine sodium Structural

What is Olsalazine sodium?

Chemical properties

Yellow Crystalline Powder

The Uses of Olsalazine sodium

Dimer of Mesalamine. It is an anti-inflammatorydrug used in the treatment of inflammatory bowel disease and ulcerative colitis

The Uses of Olsalazine sodium

Dimer of Mesalazine (M258100), an anti-inflammatory drug used in the treatment of inflammatory bowel disease and ulcerative colitis.

The Uses of Olsalazine sodium

Mordant dye for wool.

What are the applications of Application

Olsalazine Sodium is an anti-inflammatory agent

Definition

ChEBI: An organic sodium salt that is the disodium salt of 3,3'-azobis(6-hydroxybenzoic acid) (olsalazine). Effective in the treatment of inflammatory bowel disease and ulcerative colitis. Mechanism of action unknown, but appears to be topical

Preparation

5-Amino-2-chlorobenzoic acid diazotization, coupled with 2-Hydroxybenzoic acid, and then in a certain pressure and contains trace copper powder or Cupric oxide of Sodium hydroxide solution common heating (130 ~ 150 ℃).

brand name

Dipentum (UCB).

Clinical Use

Induction and maintenance of remission in ulcerative colitis

Metabolism

Olsalazine is broken down by the colonic bacterial flora into 2 molecules of 5-aminosalicylic acid (mesalazine).
The small amounts (1-2% of the dose or less) of intact olsalazine that are absorbed are excreted mainly in urine.
Approximately 0.1% of an oral dose of olsalazine is hepatically metabolised to olsalazine-O-sulfate (olsalazine-S), which has a half-life of 7 days.

Properties and Applications

deep green light yellow. Soluble in water for green light yellow, moderate soluble in Etanol for green yellow. In concentrated sulfuric acid for yellow orange, dilution after light yellow, In concentrated nitric acid to red. Dye aqueous solution to join concentrated hydrochloric acid color greatly shallow for yellow; Join concentrated Sodium hydroxide solution for golden orange.

Standard Ironing Fastness Light Fastness Fulling Persperation Fastness Soaping Water
Alkali Acid
ISO 4-5 6 4-5 2-3 4-5 5 5
AATCC 5 6-7 4 5 5 5

Properties of Olsalazine sodium

Melting point: 240 °C
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  Sparingly soluble in water, soluble in dimethyl sulfoxide, very slightly soluble in methanol.
form  neat
form  Solid
color  Light Yellow to Yellow
CAS DataBase Reference 6054-98-4(CAS DataBase Reference)
EPA Substance Registry System Benzoic acid, 3,3'-azobis[6-hydroxy-, disodium salt (6054-98-4)

Safety information for Olsalazine sodium

Computed Descriptors for Olsalazine sodium

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