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HomeProduct name listO-Phospho-L-serine

O-Phospho-L-serine

Synonym(s):L-2-Amino-3-hydroxypropanoic acid 3-phosphate;L-Serine O-phosphate;L-SOP;L-2-Amino-3-hydroxypropanoic acid 3-phosphate, L-SOP, L-Serine O-phosphate;Monoclonal Anti-Phosphoserine

  • CAS NO.:407-41-0
  • Empirical Formula: C3H8NO6P
  • Molecular Weight: 185.07
  • MDL number: MFCD00065935
  • EINECS: 206-986-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
O-Phospho-L-serine Structural

What is O-Phospho-L-serine?

Description

O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.

Description

L-O-Phosphoserine is a biomolecule that is used in combination with?L-glutamine and vitamin B12?as a “roborant”—a restorative tonic—marketed under the trade names Vitasprint B12?and Fosforina B12. It is biosynthesized via the enzymatic phosphorylation of?L-serine. F. C. Neuhaus and S. Korkes described the preparation of the racemic mixture in 1958. In 2011, C. J. Noren, J. Rinehart, and D. S?ll developed?a way to genetically encode L-O-phosphoserine?anywhere in a protein sequence.

Chemical properties

White powder

The Uses of O-Phospho-L-serine

O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.

The Uses of O-Phospho-L-serine

roborant

The Uses of O-Phospho-L-serine

L-O-Phosphoserine is the catalytic domain of human protein kinase C β II when complexed with a malemide inhibitor. It is also used in the purification of the Epstein-Barr virus nuclear antigen 2A.

What are the applications of Application

O-Phospho-L-serine is a competitive NMDA antagonist/ group III mGluR agonist

Definition

ChEBI: O-phospho-L-serine is the L-enantiomer of O-phosphoserine. It has a role as an EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, an EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor, an EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor and a mouse metabolite. It is a conjugate acid of an O-phosphonato-L-serine(2-). It is an enantiomer of an O-phospho-D-serine.

General Description

Monoclonal Anti-Phosphoserine (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

Flammability and Explosibility

Not classified

Biological Activity

Group III metabotropic glutamate receptor agonist; analog of L-AP4 (L-(+)-2-Amino-4-phosphonobutyric acid ). Inhibits proliferation and enhances neuronal differentiation in progenitor cells.

Biochem/physiol Actions

Protein phosphorylation and dephosphorylation are basic signaling mechanisms that modify protein function in eukaryotic cells. Phosphorylation is a rare posttranslational event in normal tissues, however, the abundance of phosphorylated cellular proteins increases several folds following various activation processes. The main amino acids that are phosphorylated are tyrosine, serine, or threonine (pTyr/pSer/pThr), each having specific kinases that phosphorylate them and specific phosphatases that dephosphorylate them. Mono and polyclonal antibodies directed against phosphorylated residues were generated and found useful as analytical and preparative tools by enabling the identification, quantification, and immunoaffinity isolation of phosphorylated cellular proteins.

storage

Room temperature

Purification Methods

Recrystallise the phospho-serine by dissolving 10g in H2O (150mL) at 25o, stirring for up to 20minutes. Undissolved material is filtered off (Büchner), and 95% EtOH (85mL) is added dropwise during 4minutes, and set aside at 25o for 3hours, then at 3o overnight. The crystals are washed with 95% EtOH (100mL), then dry Et2O (50mL), and dried in a vacuum (yield 6.5g). A further quantity (1.5g) can be obtained by keeping the mother liquors and washings at -10o for 1 week. The DL-isomer has m 167-170o(dec) after recrystallisation from H2O/EtOH or MeOH. [Neuhaus & Korkes Biochemical Preparations 6 75 1958, Neuhaus & Byrne J Biol Chem 234 113 1959, IR: F.lsch & Mellander Acta Chem Scand 11 1232 1957, Beilstein 4 IV 3120.]

Properties of O-Phospho-L-serine

Melting point: 190 °C(lit.)
Boiling point: 475.4±55.0 °C(Predicted)
alpha  [α]D20 +14~+18°(c=5,dil.HCl)
Density  1.809±0.06 g/cm3(Predicted)
vapor pressure  0Pa at 20℃
storage temp.  under inert gas
solubility  H2O: 50 mg/mL hot, clear, colorless to slightly yellow
pka pK1:2.08;pK2:5.65;pK3:9.74 (25°C)
form  Crystalline Powder
color  White
Water Solubility  28.34g/L at 20℃
Merck  14,7363
BRN  1726826
CAS DataBase Reference 407-41-0(CAS DataBase Reference)

Safety information for O-Phospho-L-serine

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for O-Phospho-L-serine

InChIKey BZQFBWGGLXLEPQ-UWTATZPHSA-N

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