NSC697923

Synonym(s):2-[(4-Methylphenyl)sulfonyl]-5-nitro-Furan;2-Nitro-5-tosylfuran;NSC697923, UBE2N Inhibitor, Ubiquitin-Conjugating Enzyme E2 N Inhibitor, 2-Nitro-5-tosylfuran, Ubc13 Inhibitor;UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem

CAS NO.：343351-67-7
Empirical Formula: C11H9NO5S
Molecular Weight: 267.25786
MDL number: MFCD01925132
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is NSC697923?

Description

NSC-69723 (343351-67-7) is a selective inhibitor of the E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1?Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3?Induces neuroblastoma cell death via activation of p53 and JNK.4

The Uses of NSC697923

NSC 697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A and exhibits potent cytotoxicity in a panel of Neuroblastoma (NB) cell lines. NSC 697923 also inhibits the proliferation and survival of diffuse large B-cell lymphoma cells (DLBCL).

What are the applications of Application

NSC697923 is a selective inhibitor of Ubc13-Uev1A

storage

+4°C

References

1) Pulvino et al.?(2012),?Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A; Blood,?120?1668 2) Strickson?et al.?(2013),?The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signaling network by targeting the ubiquitin system; Biochem. J.,?451?427 3) Hodge?et al.?(2015),?Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting; ACS Chem. Biol.,?10?1718 4) Cheng?et al.?(2014),?A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways; Cell Death Dis.,?5?e1079

Properties of NSC697923

Melting point:	124-126°C
Boiling point:	443.8±40.0 °C(Predicted)
Density	1.416±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
color	white to beige
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety information for NSC697923

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.