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HomeProduct name listMotesanib

Motesanib

Motesanib Structural

What is Motesanib?

Chemical properties

Pale Yellow Solid

The Uses of Motesanib

Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.

The Uses of Motesanib

Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.

What are the applications of Application

Motesanib is an inhibitor of Flk-1, Flt-4, PDGFR-β and c-Kit.

Definition

ChEBI: Motesanib is a pyridinecarboxamide.

Properties of Motesanib

Melting point: 147-150°C
Boiling point: 517.3±50.0 °C(Predicted)
Density  1.251
storage temp.  Refrigerator
solubility  DMSO (Slightly), Methanol (Slightly)
form  White powder solid.
pka 11.75±0.40(Predicted)
color  Pale Yellow

Safety information for Motesanib

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Motesanib

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