Motesanib
- CAS NO.:453562-69-1
- Empirical Formula: C22H23N5O
- Molecular Weight: 373.45
- MDL number: MFCD10567689
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 16:42:00
What is Motesanib?
Chemical properties
Pale Yellow Solid
The Uses of Motesanib
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.
The Uses of Motesanib
Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.
What are the applications of Application
Motesanib is an inhibitor of Flk-1, Flt-4, PDGFR-β and c-Kit.
Definition
ChEBI: Motesanib is a pyridinecarboxamide.
Properties of Motesanib
Melting point: | 147-150°C |
Boiling point: | 517.3±50.0 °C(Predicted) |
Density | 1.251 |
storage temp. | Refrigerator |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | White powder solid. |
pka | 11.75±0.40(Predicted) |
color | Pale Yellow |
Safety information for Motesanib
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Motesanib
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
ERK Inhibitor
N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE
Compound 23
ETHANE
Dimethyl ether
Dimethyl phthalate
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