N,N,N',N'-Tetramethylazodicarboxamide

Synonym(s):N,N,N′,N′-Tetramethylazodicarboxamide;1,1′-Azobis(N,N-dimethylformamide);Azodicarboxylic acid bis(dimethylamide);Diazenedicarboxylic acid bis(N,N-dimethylamide);TMAD

CAS NO.：10465-78-8
Empirical Formula: C6H12N4O2
Molecular Weight: 172.19
MDL number: MFCD00008318
EINECS: 233-951-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-31 18:15:48

N,N,N',N'-Tetramethylazodicarboxamide Structural

What is N,N,N',N'-Tetramethylazodicarboxamide?

Chemical properties

Yellow crystals

The Uses of N,N,N',N'-Tetramethylazodicarboxamide

Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.

Definition

ChEBI: 1,1'-azobis(N,N-dimethylformamide) is a monoazo compound.

Synthesis Reference(s)

The Journal of Organic Chemistry, 38, p. 1652, 1973 DOI: 10.1021/jo00949a007

Properties of N,N,N',N'-Tetramethylazodicarboxamide

Melting point:	112 °C
Boiling point:	220.4±23.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	soluble in Methanol
form	crystalline
pka	-0?+-.0.70(Predicted)
color	yellow
BRN	1910409
InChI	InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
CAS DataBase Reference	10465-78-8(CAS DataBase Reference)

Safety information for N,N,N',N'-Tetramethylazodicarboxamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed.