N,N,N',N'-Tetramethylazodicarboxamide
Synonym(s):N,N,N′,N′-Tetramethylazodicarboxamide;1,1′-Azobis(N,N-dimethylformamide);Azodicarboxylic acid bis(dimethylamide);Diazenedicarboxylic acid bis(N,N-dimethylamide);TMAD
- CAS NO.：10465-78-8
- Empirical Formula: C6H12N4O2
- Molecular Weight: 172.19
- MDL number: MFCD00008318
- EINECS: 233-951-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-23 21:30:31
What is N,N,N',N'-Tetramethylazodicarboxamide?
Chemical properties
Yellow crystals
The Uses of N,N,N',N'-Tetramethylazodicarboxamide
Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.
Definition
ChEBI: 1,1'-azobis(N,N-dimethylformamide) is a monoazo compound.
Synthesis Reference(s)
The Journal of Organic Chemistry, 38, p. 1652, 1973 DOI: 10.1021/jo00949a007
Properties of N,N,N',N'-Tetramethylazodicarboxamide
| Melting point: | 112 °C |
| Boiling point: | 220.4±23.0 °C(Predicted) |
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | soluble in Methanol |
| form | crystalline |
| pka | -0?+-.0.70(Predicted) |
| color | yellow |
| BRN | 1910409 |
| InChI | InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+ |
| CAS DataBase Reference | 10465-78-8(CAS DataBase Reference) |
Safety information for N,N,N',N'-Tetramethylazodicarboxamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for N,N,N',N'-Tetramethylazodicarboxamide
| InChIKey | VLSDXINSOMDCBK-BQYQJAHWSA-N |
| SMILES | C(=O)(/N=N/C(=O)N(C)C)N(C)C |
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