Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listN,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Structural

What is N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)?

Description

TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 1.5 μM for human PRMT1 in a methylation assay). It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 μM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI50s = 1.97 and 4.49 μM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.

The Uses of N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)

NSC 30176 is a inhibitor of human PRMT1, it is selective for PRMT1 over the arginine methyltransferase CARM1 and the lysine methyltransferase Set7/9.

What are the applications of Application

TC-E 5003 is a selective PRMT1 inhibitor

References

1) Bissinger?et al. (2011),?Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methytransferase hPRMT1; Bioorg. Med. Chem.,?19?3717

Properties of N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)

Melting point: 191-192 °C
Boiling point: 704.2±60.0 °C(Predicted)
Density  1.504±0.06 g/cm3(Predicted)
storage temp.  -20°C (des.)
solubility  Soluble in DMSO (up to 50 mg/ml).
pka 11.56±0.70(Predicted)
form  solid
color  Brown
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Safety information for N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)

Computed Descriptors for N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)

Related products of tetrahydrofuran

You may like

  • Tc-e 5003 95% CAS 17328-16-4
    Tc-e 5003 95% CAS 17328-16-4
    17328-16-4
    View Details
  • 4'',4''''-SULFONYLBIS(2-CHLOROACETANILIDE) CAS 17328-16-4
    4'',4''''-SULFONYLBIS(2-CHLOROACETANILIDE) CAS 17328-16-4
    17328-16-4
    View Details
  • 177-11-7 1,4-Dioxa-8-azaspiro[4.5]decane 98+
    177-11-7 1,4-Dioxa-8-azaspiro[4.5]decane 98+
    177-11-7
    View Details
  • 217299-03-1 98+
    217299-03-1 98+
    217299-03-1
    View Details
  • (R)-3-Aminobutanenitrile Hydrochloride 98+
    (R)-3-Aminobutanenitrile Hydrochloride 98+
    1073666-55-3
    View Details
  • 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 39124-20-4 98+
    4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 39124-20-4 98+
    39124-20-4
    View Details
  • 2006278-26-6 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 98+
    2006278-26-6 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 98+
    2006278-26-6
    View Details
  • 39856-50-3 98+
    39856-50-3 98+
    39856-50-3
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.