N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
- CAS NO.:17328-16-4
- Empirical Formula: C16H14Cl2N2O4S
- Molecular Weight: 401.26
- MDL number: MFCD00028183
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)?
Description
TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 1.5 μM for human PRMT1 in a methylation assay). It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 μM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI50s = 1.97 and 4.49 μM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.
The Uses of N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
NSC 30176 is a inhibitor of human PRMT1, it is selective for PRMT1 over the arginine methyltransferase CARM1 and the lysine methyltransferase Set7/9.
What are the applications of Application
TC-E 5003 is a selective PRMT1 inhibitor
References
1) Bissinger?et al. (2011),?Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methytransferase hPRMT1; Bioorg. Med. Chem.,?19?3717
Properties of N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
Melting point: | 191-192 °C |
Boiling point: | 704.2±60.0 °C(Predicted) |
Density | 1.504±0.06 g/cm3(Predicted) |
storage temp. | -20°C (des.) |
solubility | Soluble in DMSO (up to 50 mg/ml). |
pka | 11.56±0.70(Predicted) |
form | solid |
color | Brown |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
Safety information for N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
Computed Descriptors for N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
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