N,N'-Disuccinimidyl carbonate

Synonym(s):N-Succinimidyl carbonate;Di(N-succinimidyl) carbonate;Di-(N,N′-succinimidyl) carbonate;DSC;N,N′-Disuccinimidyl carbonate, Di-(N-Succinimidyl)carbonate

CAS NO.：74124-79-1
Empirical Formula: C9H8N2O7
Molecular Weight: 256.17
MDL number: MFCD00009767
EINECS: 277-730-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-08-22 13:52:55

N,N'-Disuccinimidyl carbonate Structural

What is N,N'-Disuccinimidyl carbonate?

Chemical properties

N,N'-Disuccinimidyl carbonate is white to slightly yellow crystalline powder

The Uses of N,N'-Disuccinimidyl carbonate

N,N'-Disuccinimidyl carbonate is used to prepare cleavable linker succinimide vinylsufonylethyl carbonate for thiol modified-DNA. It serves as a reagent for the synthesis of carbamates. Further, it is used as a coupling reagent as well as in the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate and coupling of ligand to proteins.

The Uses of N,N'-Disuccinimidyl carbonate

N,N’Disuccinimidyl Carbonate is a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of lig ands to proteins. The coupling reagent property of N,N’Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity.

The Uses of N,N'-Disuccinimidyl carbonate

N,N'-Disuccinimidyl carbonate is a convenient reagent for the synthesis of N-succinimidyl esters of N-protected amino acids.

What are the applications of Application

N,N′-Disuccinimidyl carbonate is a reagent for the preparation of N-succinimidyl esters

Synthesis Reference(s)

Tetrahedron Letters, 20, p. 4745, 1979 DOI: 10.1016/S0040-4039(01)86699-5

General Description

N,N′-Disuccinimidyl carbonate is used for the HPLC determination of amino compounds.

Properties of N,N'-Disuccinimidyl carbonate

Melting point:	190 °C (dec.)(lit.)
Boiling point:	399.41°C (rough estimate)
Density	1.5670 (rough estimate)
refractive index	1.5600 (estimate)
storage temp.	-20°C
solubility	Dichloromethane (Slightly, Heated), DMSO
form	Crystalline Powder
color	White to slightly yellow
Water Solubility	Soluble in dimethyl sulfoxide, hot pyridine, acetonitrile and most organic solvents. Insoluble in water.
BRN	1499137
Stability:	Moisture Sensitive
CAS DataBase Reference	74124-79-1(CAS DataBase Reference)

Safety information for N,N'-Disuccinimidyl carbonate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation H373:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P314:Get medical advice/attention if you feel unwell. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.