N-Boc-cadaverine
Synonym(s):N-Boc-1,5-diaminopentane;tert-Butyl N-(5-aminopentyl)carbamate
- CAS NO.：51644-96-3
- Empirical Formula: C10H22N2O2
- Molecular Weight: 202.29
- MDL number: MFCD00210020
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:37
What is N-Boc-cadaverine?
Description
tert-Butyl (5-aminopentyl)carbamate can be used as a PROTAC linker in the synthesis of PROTACs. tert-Butyl (5-aminopentyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
The Uses of N-Boc-cadaverine
N-Boc-cadaverine is an intermediate in the synthesis of derivative of the folic acid antagonist Methotrexate (M260675) used in the study of membrane-associated folate transporters from L1210 cells.
The Uses of N-Boc-cadaverine
Some of the reported applications of N-Boc-cadaverine include:
- Synthesis of of a supermacrocycle that self-assemble to form organic nanotubes.
- Preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye.
- Synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).
Properties of N-Boc-cadaverine
| Boiling point: | 309.2±25.0 °C(Predicted) |
| Density | 0.972 g/mL at 20 °C(lit.) |
| refractive index | n |
| Flash point: | 109 °C |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| form | Oil |
| pka | 12.91±0.46(Predicted) |
| color | Yellow |
| BRN | 3603658 |
| CAS DataBase Reference | 51644-96-3(CAS DataBase Reference) |
Safety information for N-Boc-cadaverine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for N-Boc-cadaverine
| InChIKey | DPLOGSUBQDREOU-UHFFFAOYSA-N |
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