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HomeProduct name listNimetazepam

Nimetazepam

  • CAS NO.:2011-67-8
  • Empirical Formula: C16H13N3O3
  • Molecular Weight: 295.29
  • MDL number: MFCD00242916
  • EINECS: 217-931-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 09:02:36
Nimetazepam Structural

What is Nimetazepam?

Chemical properties

Dark yellow Solid

Originator

Erimin,Sumitomo,Japan,1977

The Uses of Nimetazepam

Sedative, hypnotic. Controlled substance.

Definition

ChEBI: A nitrazepam which is substituted at positions 1 by a methyl groups. It is used as an anticonvulsant and as a hypnotic for the short-term management of insomnia.

Manufacturing Process

To a suspension of 73.9 g of 1-methyl-5-nitro-3-phenylindole-2-carbonitrile in 1.5 liters of dry tetrahydrofuran is added dropwise a solution of 126 g of boron trifluoride etherate in 220 ml of dry tetrahydrofuran with stirring for 2 hours. After addition, stirring is continued for an additional 3 hours. To the reaction mixture is added dropwise 370 ml of water and then 370 ml of concentrated hydrochloric acid with stirring under ice-cooling.
The resulting precipitate is collected by filtration, washed with water followed by ethanol, and dried to give 56.3 g of crude 2-aminomethyl-1-methyl-5- nitro-3-phenylindole hydrochloride, melting point 263°C to 267°C.
To a suspension of 6.5 g of 2-aminomethyl-1-methyl-5-nitro-3-phenylindole in 65 ml of glacial acetic acid is added dropwise a solution of 6.5 g of chromic anhydride in 6.5 ml of water at 20°C with stirring. The mixture is stirred at room temperature overnight and thereto is added 195 ml of water. To the mixture is added dropwise 100 ml of 28% ammonia water with stirring under cooling. The resultant precipitate is collected by filtration, washed with water and dried to give 5.9 g of a crude product having melting point 135°C to 140°C. Fractional recrystallization from ethanol gives 3.8 g of 1-methyl-7- nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepine-2-one as yellow plates, melting point 153°C to 156°C. Further recrystallization from the same solvent gives pale yellow plates having melting point 156°C to 156.5°C.

Therapeutic Function

Tranquilizer

Properties of Nimetazepam

Melting point: 156.5-157.5°
Boiling point: 436.98°C (rough estimate)
Density  1.1952 (rough estimate)
refractive index  1.6500 (estimate)
Flash point: 9℃
storage temp.  -20°C
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
pka pKa 2.53(EtOH/H2O,t =25,Iundefined) (Uncertain)
color  Light Yellow to Dark Yellow
CAS DataBase Reference 2011-67-8(CAS DataBase Reference)
NIST Chemistry Reference Nimetazepam(2011-67-8)

Safety information for Nimetazepam

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H225:Flammable liquids
H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P311:Call a POISON CENTER or doctor/physician.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for Nimetazepam

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