NICOTINIC ACID HYDRAZIDE
Synonym(s):Nicotinic acid hydrazide
- CAS NO.：553-53-7
- Empirical Formula: C6H7N3O
- Molecular Weight: 137.14
- MDL number: MFCD00006383
- EINECS: 209-041-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:03
What is NICOTINIC ACID HYDRAZIDE?
Chemical properties
WHITE TO OFF-WHITE FINE NEEDLE-LIKE CRYST. POWDER
The Uses of NICOTINIC ACID HYDRAZIDE
Nicotinic hydrazide was used in hydrazone library formation. It was used to study the oxidation of isonicotinic acid hydrazide (isoniazid) by horseradish peroxidase.
The Uses of NICOTINIC ACID HYDRAZIDE
An Impurity of Isoniazid (I821450), potent antitubercular agent against M. tuberculosis.
Biochem/physiol Actions
Nicotinic hydrazide is an inhibitor of peroxidase enzyme. It forms solid metal complexes having strong biological activity.
Purification Methods
Crystallise it from aqueous EtOH or *benzene. [Beilstein 22 III/IV 439, 22/2 V 121.]
Properties of NICOTINIC ACID HYDRAZIDE
| Melting point: | 159-161 °C(lit.) |
| Boiling point: | 251.97°C (rough estimate) |
| Density | 1.2620 (rough estimate) |
| refractive index | 1.6910 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | H2O: soluble50mg/mL |
| pka | 11.43±0.10(Predicted) |
| form | Fine Needle-Like Crystalline Powder |
| color | White to off-white |
| Water Solubility | Soluble in alcohol, water. |
| BRN | 119299 |
| CAS DataBase Reference | 553-53-7(CAS DataBase Reference) |
Safety information for NICOTINIC ACID HYDRAZIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for NICOTINIC ACID HYDRAZIDE
| InChIKey | KFUSANSHCADHNJ-UHFFFAOYSA-N |
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