Nicotinamide-N-oxide
- CAS NO.：1986-81-8
- Empirical Formula: C6H6N2O2
- Molecular Weight: 138.12
- MDL number: MFCD00006202
- EINECS: 217-859-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:13
What is Nicotinamide-N-oxide?
Description
Nicotinamide N-oxide is a metabolite of nicotinamide . It is formed via oxidation of nicotinamide by the cytochrome P450 (CYP) isoform CYP2E1. Nicotinamide N-oxide (30 mM) inhibits proliferation and induces reduction of nitroblue tetrazolium (NBT; ), indicating cell differentiation, in HL-60 promyelocytic leukemia cells. Urine levels of nicotinamide N-oxide are elevated in a mouse model of high-fat diet-induced obesity.
Chemical properties
WHITE TO SLIGHTLY YELLOW FLUFFY CRYST. NEEDLES
The Uses of Nicotinamide-N-oxide
A metabolite of Nicotinamide
The Uses of Nicotinamide-N-oxide
A metabolite of Nicotinamide.
Definition
ChEBI: Nicotinamide N-oxide is a member of pyridines.
Properties of Nicotinamide-N-oxide
| Melting point: | 291-293 °C (dec.)(lit.) |
| Boiling point: | 253.51°C (rough estimate) |
| Density | 1.3471 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 14.38±0.50(Predicted) |
| color | White to Off-White |
| Sensitive | Hygroscopic |
| CAS DataBase Reference | 1986-81-8(CAS DataBase Reference) |
Safety information for Nicotinamide-N-oxide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Nicotinamide-N-oxide
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product: 1986-81-8 NICOTINAMIDE EP IMPURITY E 90 % Above
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