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HomeProduct name listNicotinamide-N-oxide

Nicotinamide-N-oxide

  • CAS NO.:1986-81-8
  • Empirical Formula: C6H6N2O2
  • Molecular Weight: 138.12
  • MDL number: MFCD00006202
  • EINECS: 217-859-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
Nicotinamide-N-oxide Structural

What is Nicotinamide-N-oxide?

Description

Nicotinamide N-oxide is a metabolite of nicotinamide . It is formed via oxidation of nicotinamide by the cytochrome P450 (CYP) isoform CYP2E1. Nicotinamide N-oxide (30 mM) inhibits proliferation and induces reduction of nitroblue tetrazolium (NBT; ), indicating cell differentiation, in HL-60 promyelocytic leukemia cells. Urine levels of nicotinamide N-oxide are elevated in a mouse model of high-fat diet-induced obesity.

Chemical properties

WHITE TO SLIGHTLY YELLOW FLUFFY CRYST. NEEDLES

The Uses of Nicotinamide-N-oxide

A metabolite of Nicotinamide.

The Uses of Nicotinamide-N-oxide

A metabolite of Nicotinamide

Definition

ChEBI: Nicotinamide N-oxide is a member of pyridines.

Properties of Nicotinamide-N-oxide

Melting point: 291-293 °C (dec.)(lit.)
Boiling point: 253.51°C (rough estimate)
Density  1.3471 (rough estimate)
refractive index  1.5100 (estimate)
storage temp.  Inert atmosphere,Room Temperature
solubility  DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form  Solid
pka 14.38±0.50(Predicted)
color  White to Off-White
Sensitive  Hygroscopic
CAS DataBase Reference 1986-81-8(CAS DataBase Reference)

Safety information for Nicotinamide-N-oxide

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for Nicotinamide-N-oxide

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