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HomeProduct name listNG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

Synonym(s):asym-Dimethylarginine;ADMA;ADMA, 2HCl;NG,NG-Dimethyl-L-arginine, Dihydrochloride - CAS 220805-22-1 - Calbiochem

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Structural

What is NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE?

Chemical properties

White Crystalline Solid

The Uses of NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells

The Uses of NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

NG,NG- Dimethylarginine dihydrochloride has been used:

  • to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
  • as a standard for measuring L-arginine and dimethylarginines
  • to study its effects on hepatic deterioration

What are the applications of Application

NG,NG-Dimethylarginine Dihydrochloride is a cell-permeable, reversible inhibitor of nitric oxide synthase

General Description

NG,NG-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).

Biological Activity

ng,ng-dimethyl-l-arginine is an endogenous nitric oxide synthase inhibitor.nitric oxide (no) that is synthesised from l-arginine contributes to the regulation of blood pressure and to host defence.

Biochem/physiol Actions

Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.

in vitro

ng,ng-dimethyl-l-arginine (adma) was found to be able to inhibit macrophage and vascular no synthase. when added to a cytosolic preparation of macrophage no synthase, adma could cause dose-dependent inhibition of no formation. in the presence of added arginine, adma could inhibited no synthesis and the inhibitory effects of adma were prevented by addition of l-arginine so that the rate of no synthesis did not significantly differ from control values [1].

in vivo

animal study showed that the injection of 1-30 mg/kg adma into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. moreover, during continuous infusion of adma, which caused plasma adma concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].

storage

Room temperature (desiccate)

References

[1] vallance, p. ,leone, a.,calver, a., et al. accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. lancet 339, 572-575 (1992).

Properties of NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

Melting point: 202-204OC
storage temp.  room temp
solubility  DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
form  White to off-white crystalline solid.
color  White to Off-White
Water Solubility  Soluble in water (100 mM)
Stability: Store at 0-5°C; Moisture Sensitive; Hygroscopic
CAS DataBase Reference 220805-22-1

Safety information for NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

Computed Descriptors for NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

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