NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
Synonym(s):asym-Dimethylarginine;ADMA;ADMA, 2HCl;NG,NG-Dimethyl-L-arginine, Dihydrochloride - CAS 220805-22-1 - Calbiochem
- CAS NO.:220805-22-1
- Empirical Formula: C8H20Cl2N4O2
- Molecular Weight: 275.18
- MDL number: MFCD00270857
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 13:32:20
What is NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE?
Chemical properties
White Crystalline Solid
The Uses of NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells
The Uses of NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
NG,NG- Dimethylarginine dihydrochloride has been used:
- to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
- as a standard for measuring L-arginine and dimethylarginines
- to study its effects on hepatic deterioration
What are the applications of Application
NG,NG-Dimethylarginine Dihydrochloride is a cell-permeable, reversible inhibitor of nitric oxide synthase
General Description
NG,NG-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).
Biological Activity
ng,ng-dimethyl-l-arginine is an endogenous nitric oxide synthase inhibitor.nitric oxide (no) that is synthesised from l-arginine contributes to the regulation of blood pressure and to host defence.
Biochem/physiol Actions
Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.
in vitro
ng,ng-dimethyl-l-arginine (adma) was found to be able to inhibit macrophage and vascular no synthase. when added to a cytosolic preparation of macrophage no synthase, adma could cause dose-dependent inhibition of no formation. in the presence of added arginine, adma could inhibited no synthesis and the inhibitory effects of adma were prevented by addition of l-arginine so that the rate of no synthesis did not significantly differ from control values [1].
in vivo
animal study showed that the injection of 1-30 mg/kg adma into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. moreover, during continuous infusion of adma, which caused plasma adma concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].
storage
Room temperature (desiccate)
References
[1] vallance, p. ,leone, a.,calver, a., et al. accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. lancet 339, 572-575 (1992).
Properties of NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
Melting point: | 202-204OC |
storage temp. | room temp |
solubility | DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly) |
form | White to off-white crystalline solid. |
color | White to Off-White |
Water Solubility | Soluble in water (100 mM) |
Stability: | Store at 0-5°C; Moisture Sensitive; Hygroscopic |
CAS DataBase Reference | 220805-22-1 |
Safety information for NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
Computed Descriptors for NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
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