AMINOGUANIDINE HEMISULFATE
Synonym(s):1-Aminoguanidinium sulfate;Bis(1-aminoguanidinium) sulfate;Guanylhydrazine hemisulfate salt
- CAS NO.:996-19-0
- Empirical Formula: CH8N4O4S
- Molecular Weight: 172.16
- MDL number: MFCD00035665
- EINECS: 213-628-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is AMINOGUANIDINE HEMISULFATE?
Chemical properties
WHITE CRYSTALS OR CRYSTALLINE POWDER
The Uses of AMINOGUANIDINE HEMISULFATE
NO synthase inhibitor
The Uses of AMINOGUANIDINE HEMISULFATE
Aminoguanidine inhibits both constitutive and inducible nitric oxide synthetase. Aminoguanidine has also been used to study the effects of nitric oxide on ovulation and ovarian steroidogenesis and prostaglandin production.
What are the applications of Application
Aminoguanidine hemisulfate is a NOS (nitric oxide synthase) inhibitor
What are the applications of Application
Aminoguanidine hemisulfate is used in the treatment of patients with chronic granulomatous disease, which is a form of leukemia. This drug also has been shown to inhibit follicular growth and nitrogen atoms, as well as to inhibit the production of protein-bound polyamines. It was found to have no effect on the intracellular calcium concentration or on growth factor release by receptor cells. It has been shown that it can inhibit cyclase activity and therefore reduce proliferation of cells in experimental models. The ester hydrochloride salt of this compound is an inhibitor of guanylate cyclase, which prevents the conversion of guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP).
Biochem/physiol Actions
Inhibits both constitutive and inducible nitric oxide synthetase
Properties of AMINOGUANIDINE HEMISULFATE
Melting point: | 200 °C |
Density | 1.36 g/cm3 (20℃) |
storage temp. | Store below +30°C. |
solubility | 170g/l |
form | White solid. |
color | White to Almost white |
PH | 4-6 (25g/l, H2O, 20℃) |
Water Solubility | almost transparency |
CAS DataBase Reference | 996-19-0(CAS DataBase Reference) |
EPA Substance Registry System | Hydrazinecarboximidamide, sulfate (2:1) (996-19-0) |
Safety information for AMINOGUANIDINE HEMISULFATE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for AMINOGUANIDINE HEMISULFATE
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