NG-MONOMETHYL-L-ARGININE ACETATE
Synonym(s):Nω-Methyl-L -arginine acetate salt;L -NMMA;N ω-Me-L-Arg, N G-Me-L-Arg, AcOH, L-NMMA;Nω-Me-L-Arg, NG-Me-L-Arg, AcOH, L-NMMA;N5-(Methylamidino)-L -ornithine acetate salt
- CAS NO.:53308-83-1
- Empirical Formula: C9H20N4O4
- Molecular Weight: 248.28
- MDL number: MFCD00069311
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-30 20:13:01
What is NG-MONOMETHYL-L-ARGININE ACETATE?
Description
L-
Chemical properties
White Crystalline Powder
The Uses of NG-MONOMETHYL-L-ARGININE ACETATE
A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells
The Uses of NG-MONOMETHYL-L-ARGININE ACETATE
Reagent to inhibit nitric oxide production in biological systems.
The Uses of NG-MONOMETHYL-L-ARGININE ACETATE
Nitric oxide synthase inhibitor
What are the applications of Application
L-NG-Monomethylarginine, Acetate Salt (L-NMMA) is an L-arginine analogue inhibitor of Ca2+-dependent NOS3 (endothelial NOS)
Biological Activity
Competitive, irreversible inhibitor of all three NOS isoforms.
Biochem/physiol Actions
NG-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.
storage
Room temperature
Properties of NG-MONOMETHYL-L-ARGININE ACETATE
Melting point: | 180-190 °C |
Boiling point: | 391.35°C (rough estimate) |
alpha | D22 +9.5° (c = 0.10 in water) |
Density | 1.2162 (rough estimate) |
refractive index | 1.6300 (estimate) |
storage temp. | 2-8°C |
solubility | H2O: 1 mg/mL, clear, colorless |
form | Powder |
color | White to Off-white |
Water Solubility | Soluble in water (50 mM) |
BRN | 6674255 |
Stability: | Store at - 5°C; Desiccate Recommended |
Safety information for NG-MONOMETHYL-L-ARGININE ACETATE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NG-MONOMETHYL-L-ARGININE ACETATE
InChIKey | IKPNWIGTWUZCKM-JEDNCBNOSA-N |
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