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HomeProduct name listNG-MONOMETHYL-L-ARGININE ACETATE

NG-MONOMETHYL-L-ARGININE ACETATE

Synonym(s):Nω-Methyl-L-arginine acetate salt;L-NMMA;N ω-Me-L-Arg, N G-Me-L-Arg, AcOH, L-NMMA;Nω-Me-L-Arg, NG-Me-L-Arg, AcOH, L-NMMA;N5-(Methylamidino)-L-ornithine acetate salt

NG-MONOMETHYL-L-ARGININE ACETATE Structural

What is NG-MONOMETHYL-L-ARGININE ACETATE?

Description

L-NMMA is the archetypal competitive NOS inhibitor to which other inhibitors are often compared. It is a relatively non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 μM, respectively.

Chemical properties

White Crystalline Powder

The Uses of NG-MONOMETHYL-L-ARGININE ACETATE

A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells

The Uses of NG-MONOMETHYL-L-ARGININE ACETATE

Reagent to inhibit nitric oxide production in biological systems.

The Uses of NG-MONOMETHYL-L-ARGININE ACETATE

Nitric oxide synthase inhibitor

What are the applications of Application

L-NG-Monomethylarginine, Acetate Salt (L-NMMA) is an L-arginine analogue inhibitor of Ca2+-dependent NOS3 (endothelial NOS)

Biological Activity

Competitive, irreversible inhibitor of all three NOS isoforms.

Biochem/physiol Actions

NG-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.

storage

Room temperature

Properties of NG-MONOMETHYL-L-ARGININE ACETATE

Melting point: 180-190 °C
Boiling point: 391.35°C (rough estimate)
alpha  D22 +9.5° (c = 0.10 in water)
Density  1.2162 (rough estimate)
refractive index  1.6300 (estimate)
storage temp.  2-8°C
solubility  H2O: 1 mg/mL, clear, colorless
form  Powder
color  White to Off-white
Water Solubility  Soluble in water (50 mM)
BRN  6674255
Stability: Store at - 5°C; Desiccate Recommended

Safety information for NG-MONOMETHYL-L-ARGININE ACETATE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for NG-MONOMETHYL-L-ARGININE ACETATE

InChIKey IKPNWIGTWUZCKM-JEDNCBNOSA-N

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