Neferine
Synonym(s):(-)-Neferine;4′′-O-Methylliensinine;4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol;Methylliensinine;Neferin
- CAS NO.:2292-16-2
- Empirical Formula: C38H44N2O6
- Molecular Weight: 624.77
- MDL number: MFCD01707128
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 19:05:58
What is Neferine?
Description
A bisbenzylisoquinoline alkaloid from Nelumbo nucifera, the structure of this base has been shown to be that represented above based upon chemical degrada_x0002_tive studies and spectroscopic data. Four methoxyl groups, one hydroxyl and two methylimino groups are present.
The Uses of Neferine
Neferine is an isoquinoline alkaloid which enhances the antitumor effect of Mitomycin-C in hela cells through activation of p38-MAPK. Useful in the treatment of cervical cancers.
Definition
ChEBI: Neferine is a member of isoquinolines.
Biochem/physiol Actions
Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.
References
Yang, Chen.,J. Chin. Chem. Soc., 17,235 (1970)
Properties of Neferine
Melting point: | 59-61 °C |
Boiling point: | 710.9±60.0 °C(Predicted) |
Density | 1.185±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: >15mg/mL |
form | powder |
pka | 9.28±0.45(Predicted) |
color | white to beige |
optical activity | [α]/D -34 to -44° (c=0 3. CHCl3) |
Safety information for Neferine
Computed Descriptors for Neferine
InChIKey | MIBATSHDJRIUJK-ROJLCIKYSA-N |
Related products of tetrahydrofuran
You may like
-
Neferine CAS 2292-16-2View Details
2292-16-2 -
77-92-9 99%View Details
77-92-9 -
77-92-9 99%View Details
77-92-9 -
8000-27-9 CEDAR WOOD OIL 99%View Details
8000-27-9 -
AMMONIUM DICHROMATE 7789-09-5 99%View Details
7789-09-5 -
77-78-1 DIMETHYL SULPHATE 99%View Details
77-78-1 -
7778-80-5 POTASSIUM SULPHATE 99%View Details
7778-80-5 -
95-54-5 99%View Details
95-54-5