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HomeProduct name listNaproxen sodium

Naproxen sodium

Synonym(s):(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt

  • CAS NO.:26159-34-2
  • Empirical Formula: C14H13O3.Na
  • Molecular Weight: 252.24
  • MDL number: MFCD00058507
  • EINECS: 247-486-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-09 19:38:33
Naproxen sodium Structural

What is Naproxen sodium?

Chemical properties

White Powder

The Uses of Naproxen sodium

A cyclooxygenase inhibitorNaproxen sodium acts as a nonselective inhibitor of Cox-1 and Cox-2. It serves as an anti-inflammatory agent with analgesic and antipyretic properties. Further, it is used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea and acute gout.

The Uses of Naproxen sodium

An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory

The Uses of Naproxen sodium

Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively

What are the applications of Application

Naproxen Sodium Salt is a nonselective inhibitor of Cox-1 and Cox-2

Definition

ChEBI: The sodium salt of naproxen.

brand name

Aleve (Bayer); Anaprox (Roche);Naprelan (Stat Trade).

General Description

Naproxen sodium (NS) is a sodium salt of propionic acid derivative and demonstrates analgesic, anti-pyretic, and anti-inflammatory properties. It exhibits efficiency in being used as an indomethacin in the treatment of acute musculoskeletal disorders. It belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDS) and acts by inhibiting the activity of both the cyclooxygenase enzymes, COX-1 & COX-2 and further blocking the synthesis of certain prostaglandins. It is administered in the treatment of ankylosing spondylitis, osteoarthritis, rheumatoid disorders, acute gout, mild to moderate pain, tendonitis, bursitis, dysmenorrhea, fever, and migraine headache. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biological Activity

Non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress.

Biochem/physiol Actions

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

References

[1]. mendias cl, tatsumi r and allen re. role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion. muscle nerve, 2004, 30(4):497-500.
[2]. hinz b, cheremina o, besz d, et al. impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers. int j clin pharmacol ther, 2008, 46(4):180-6.
[3]. sances g, martignoni e, fioroni l, et al. naproxen sodium in menstrual migraine prophylaxis: a double-blind placebo controlled study. headache, 1990, 30(11):705-9.
[4]. tavolari s, bonafè m, marini m, et al. licofelone, a dual cox/5-lox inhibitor, induces apoptosis in hca-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. carcinogenesis, 2008, 29(2):371-80.

Properties of Naproxen sodium

Melting point: 250-251°C
alpha  D -11° (in methanol)
storage temp.  Inert atmosphere,Room Temperature
solubility  Freely soluble in water, freely soluble or soluble in methanol, sparingly soluble in ethanol (96 per cent).
form  neat
form  Solid
color  White to Off-White
Water Solubility  Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water.
CAS DataBase Reference 26159-34-2(CAS DataBase Reference)

Safety information for Naproxen sodium

Signal word Danger
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H360:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Naproxen sodium

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