Naproxen sodium
Synonym(s):(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt
- CAS NO.:26159-34-2
- Empirical Formula: C14H13O3.Na
- Molecular Weight: 252.24
- MDL number: MFCD00058507
- EINECS: 247-486-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-09 19:38:33
What is Naproxen sodium?
Chemical properties
White Powder
The Uses of Naproxen sodium
A cyclooxygenase inhibitorNaproxen sodium acts as a nonselective inhibitor of Cox-1 and Cox-2. It serves as an anti-inflammatory agent with analgesic and antipyretic properties. Further, it is used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea and acute gout.
The Uses of Naproxen sodium
An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory
The Uses of Naproxen sodium
Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively
What are the applications of Application
Naproxen Sodium Salt is a nonselective inhibitor of Cox-1 and Cox-2
Definition
ChEBI: The sodium salt of naproxen.
brand name
Aleve (Bayer); Anaprox (Roche);Naprelan (Stat Trade).
General Description
Naproxen sodium (NS) is a sodium salt of propionic acid derivative and demonstrates analgesic, anti-pyretic, and anti-inflammatory properties. It exhibits efficiency in being used as an indomethacin in the treatment of acute musculoskeletal disorders. It belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDS) and acts by inhibiting the activity of both the cyclooxygenase enzymes, COX-1 & COX-2 and further blocking the synthesis of certain prostaglandins. It is administered in the treatment of ankylosing spondylitis, osteoarthritis, rheumatoid disorders, acute gout, mild to moderate pain, tendonitis, bursitis, dysmenorrhea, fever, and migraine headache. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biological Activity
Non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress.
Biochem/physiol Actions
Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.
References
[1]. mendias cl, tatsumi r and allen re. role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion. muscle nerve, 2004, 30(4):497-500.
[2]. hinz b, cheremina o, besz d, et al. impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers. int j clin pharmacol ther, 2008, 46(4):180-6.
[3]. sances g, martignoni e, fioroni l, et al. naproxen sodium in menstrual migraine prophylaxis: a double-blind placebo controlled study. headache, 1990, 30(11):705-9.
[4]. tavolari s, bonafè m, marini m, et al. licofelone, a dual cox/5-lox inhibitor, induces apoptosis in hca-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. carcinogenesis, 2008, 29(2):371-80.
Properties of Naproxen sodium
Melting point: | 250-251°C |
alpha | D -11° (in methanol) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Freely soluble in water, freely soluble or soluble in methanol, sparingly soluble in ethanol (96 per cent). |
form | neat |
form | Solid |
color | White to Off-White |
Water Solubility | Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water. |
CAS DataBase Reference | 26159-34-2(CAS DataBase Reference) |
Safety information for Naproxen sodium
Signal word | Danger |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H360:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Naproxen sodium
Abamectin manufacturer
Divis Laboratories Ltd
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
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