Naftopidil dihydrochloride

Description

Naftopidil was launched in Japan for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). It can be prepared by a two step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective alpha-l-antagonist with a slightly higher affinity for the human prostatic than for the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor affinity. In experiments with rats or rabbits, Naftopidil was shown to be more potent and selective for the urodynamic effect than the hypotensive effect. Aromatic or aliphatic hydroxylation are the major routes of metabolism, producing metabolites with a profile similar to the parent compound.

Chemical properties

Off-White Solid

Originator

Boehringer Mannheim (Germany)

The Uses of Naftopidil dihydrochloride

A α-1-Adrenergic receptor antagonist, antihypertensive.

The Uses of Naftopidil dihydrochloride

antihypertensive, alpha-blocker, 5HT1a agonist

The Uses of Naftopidil dihydrochloride

Naftopidil is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive.

What are the applications of Application

Naftopidil is N α-1-Adrenergic receptor antagonist and an antihypertensive.

Definition

ChEBI: Naftopidil is a member of piperazines.

brand name

Avishot;Flivas

Biological Activity

An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator.