N-Succinimidyl 6-maleimidohexanoate
Synonym(s):N-(ε-Maleimidocaproyloxy)succinimide;N-Succinimidyl 6-maleimidocaproate;6-Maleimidocaproic acid N-succinimidyl ester;EMCS
- CAS NO.:55750-63-5
- Empirical Formula: C14H16N2O6
- Molecular Weight: 308.29
- MDL number: MFCD00043043
- EINECS: 637-238-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:51:00
What is N-Succinimidyl 6-maleimidohexanoate?
Description
Mal-heptanoic NHS ester contains a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Chemical properties
White to cream colored crystals
The Uses of N-Succinimidyl 6-maleimidohexanoate
6-Maleimidohexanoic acid N-hydroxysuccinimide ester can be used in:
- Synthesis of maleimide-activated carbohydrates for site-specific glycosylation of cysteine-containing peptides and proteins via maleimide-thiol ligation reaction.
- Synthesis of a glucuronide prodrug of doxorubicin bearing a maleimide side chain as an antitumor agent.
- Cross-linking oligonucleotides with the amino groups on the substrate to fabricate DNA microarrays.
What are the applications of Application
6-Maleimidohexanoic acid N-hydroxysuccinimide ester is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity
Properties of N-Succinimidyl 6-maleimidohexanoate
Melting point: | 70-73 °C(lit.) |
Boiling point: | 480.6±47.0 °C(Predicted) |
Density | 1.40±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | chloroform: 100mg/mL |
form | powder |
pka | -2.21±0.20(Predicted) |
color | Off-white to pale brown |
Sensitive | Light & Moisture Sensitive & Hygroscopic |
BRN | 1499815 |
InChI | InChI=1S/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2 |
CAS DataBase Reference | 55750-63-5(CAS DataBase Reference) |
Safety information for N-Succinimidyl 6-maleimidohexanoate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-Succinimidyl 6-maleimidohexanoate
InChIKey | VLARLSIGSPVYHX-UHFFFAOYSA-N |
SMILES | N1(CCCCCC(ON2C(=O)CCC2=O)=O)C(=O)C=CC1=O |
New Products
Bromine 99.5% AR (4 x 500ml) Fehling's Solution No. B Amino Acid Kit of 23 items set Ammonium Molybdate Reagent Solution Beam's Reagent Solution Ehrlich's Reagent For detection of urobillinogen Sodium Amino Salicylate Dihydrate (PAS Sodium) IP/BP/USP/EP 1,2,3,4-Tetrahydrocarbazol-4-one 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 2 – Methoxy – 5- Sulfamoyl Benzoic acid Acetone Isobutryl oxime ester Curcuma aromatica Oil Curry leaf Extract Terminalia bellirica Extract Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride 5-Nitrosalicylaldehyde 5-(Difluoromethoxy)-2-Mercapto-1H-Benzimidazole- IP/BP/ Methyl Di Chloride (Mdc)Related products of tetrahydrofuran
N-Succinimidyl 3-maleimidopropionate
Bismaleimide
Succinimide
Methyl acrylate
Hexyl hexanoate
O-Phthalimide
DIALIFOS
N-Chlorosuccinimide
You may like
-
N-Succinimidyl 6-maleimidohexanoate 98% CAS 55750-63-5View Details
55750-63-5 -
N-(epsilon-Maleimidocaproyloxy) Succinimide extrapure CAS 55750-63-5View Details
55750-63-5 -
N-Succinimidyl 6-Maleimidohexanoate [Cross-linking Reagent] CAS 55750-63-5View Details
55750-63-5 -
N-Succinimidyl 6-maleimidohexanoate 98% (HPLC) CAS 55750-63-5View Details
55750-63-5 -
6-Maleimidohexanoic acid N-hydroxysuccinimide ester CAS 55750-63-5View Details
55750-63-5 -
6-Maleimidohexanoic acid N-hydroxysuccinimide ester CAS 55750-63-5View Details
55750-63-5 -
6-Maleimidohexanoic acid N-hydroxysuccinimide ester CAS 55750-63-5View Details
55750-63-5 -
7726-95-6 Bromine 99.5% AR (4 x 500ml) 99%View Details
7726-95-6
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.