N-Methyl-4-piperidinol

Synonym(s):1-Methyl-4-piperidinol;4-Hydroxy-1-methylpiperidine

CAS NO.：106-52-5
Empirical Formula: C6H13NO
Molecular Weight: 115.17
MDL number: MFCD00006500
EINECS: 203-406-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-05 20:55:42

What is N-Methyl-4-piperidinol ?

Chemical properties

clear colorless to yellowish liquid after melting

The Uses of N-Methyl-4-piperidinol

Reactant for:• ;Optimization of Novobiocin scaffold to product antitumor agents1• ;Substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis2Reactant for synthesis of:• ;CaMKII inhibitors3• ;VEGFR and FGFR kinase inhibitors4• ;Phosphoinositide-3-kinase inhibitors5• ;Protein lysine methyltransferase G9a inhibitors6

The Uses of N-Methyl-4-piperidinol

4-Hydroxy-1-methylpiperidine is used as reactant for optimization of Novobiocin scaffold to product antitumor agents, substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis. It is also used as a reactant in the synthesis of CaMKII, VEGFR and FGFR kinase inhibitors and Phosphoinositide-3-kinase, Protein lysine methyltransferase G9a inhibitors.

Flammability and Explosibility

Not classified

Properties of N-Methyl-4-piperidinol

Melting point:	29-31 °C(lit.)
Boiling point:	200 °C(lit.)
Density	0.98 g/mL at 20 °C(lit.)
vapor pressure	8.13-11Pa at 25℃
refractive index	n20/D 1.479
Flash point:	190 °F
storage temp.	2-8°C
form	Liquid After Melting
pka	14.87±0.20(Predicted)
color	Clear colorless to brown
Water Solubility	MISCIBLE
Sensitive	Hygroscopic
BRN	103024
CAS DataBase Reference	106-52-5(CAS DataBase Reference)
NIST Chemistry Reference	4-Hydroxy-N-methylpiperidine(106-52-5)
EPA Substance Registry System	4-Piperidinol, 1-methyl- (106-52-5)

Safety information for N-Methyl-4-piperidinol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.