N-Isopropylacrylamide

Synonym(s):NIPAM

CAS NO.：2210-25-5
Empirical Formula: C6H11NO
Molecular Weight: 113.16
MDL number: MFCD00041913
EINECS: 218-638-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-20 11:41:24

What is N-Isopropylacrylamide?

Description

N-Isopropylacrylamide (NIPAM) is a biocompatible monomeric unit that can be used in the formation of stimuli responsive polymers due to its temperature sensitive properties, which include temperature-based volumetric and phase changes. These properties change when the temperature of the solution reaches a lower critical solution temperature (LCST).

Chemical properties

white to light yellow crystalline powder or

The Uses of N-Isopropylacrylamide

Binders in textiles, paper, adhesives, detergents, cosmetics.
N-Isopropylacrylamide is used to produce poly(N-isopropylacrylamide) (pNIPA, pNIPAAm, pNIPAA or pNIPAm) thermo sensitive polymer- or copolymer-based hydrogels. Polymers that contain NIPAM shrink dramatically above 33°C. Monomer used in the preparation of thermally sensitive, water-swellable hydrogels.

The Uses of N-Isopropylacrylamide

NIPAM can be used to prepare poly(NIPAM) for a variety of applications such as tissue engineering, cell culture, biomedical coating, drug delivery, and muscle regeneration.

What are the applications of Application

N-Isopropylacrylamide (NIPAM) can be used to prepare poly(NIPAM) based thermosetting polymers, which can be used for a variety of applications such as tissue engineering, cell culture, biomedical coating, drug delivery, and muscle regeneration.
Monomer used in the preparation of thermally sensitive, water-swellable hydrogels.

General Description

N-Isopropylacrylamide (NIPAM) is a biocompatible monomeric unit that can be used in the formation of stimuli responsive polymers due to its temperature sensitive properties. These properties include temperature based volumetric and phase changes, which change when the temperature of the solution reaches a lower critical solution temperature (LCST).

Flammability and Explosibility

Not classified

Purification Methods

Fractionate the amide under reduced pressure, and recrystallise the solid distillate from hexane (m 59o), *C6H6 (m 62o) or *C6H6/hexane (m 62-63o). Store it with 0.05% of 4-tert-butylcatechol. It is used for making water soluble swellable hydrogels. [Beilstein 4 IV 517.]

Properties of N-Isopropylacrylamide

Melting point:	60-63 °C(lit.)
Boiling point:	89-92 °C2 mm Hg(lit.)
Density	1.0223 (rough estimate)
refractive index	1.4210 (estimate)
storage temp.	2-8°C
form	Crystalline Powder or Crystals
pka	14.83±0.46(Predicted)
color	White to light yellow
PH	pH(50g/l, 25℃) : 7.8～10.0
Water Solubility	Slightly soluble in water.
CAS DataBase Reference	2210-25-5(CAS DataBase Reference)
NIST Chemistry Reference	Acrylamide, n-isopropyl-(2210-25-5)
EPA Substance Registry System	2-Propenamide, N-(1-methylethyl)- (2210-25-5)

Safety information for N-Isopropylacrylamide

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P501:Dispose of contents/container to..…