N,N'-Methylenebisacrylamide

Synonym(s):BIS;BIS, Bisacrylamide solution;Bis-acrylamide;N,N′-Methylenebisacrylamide;N,N′-Methylenediacrylamide

CAS NO.：110-26-9
Empirical Formula: C7H10N2O2
Molecular Weight: 154.17
MDL number: MFCD00008625
EINECS: 203-750-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-31 13:32:20

What is N,N'-Methylenebisacrylamide?

Chemical properties

white crystalline powder

The Uses of N,N'-Methylenebisacrylamide

N,N'-Methylenebisacrylamide is used in the preparation of polyacrylamide gels for electrophoretic separation of nucleic acids and proteins. It has also been used as a test compound for studying the biochemical isolation of insoluble Tau in transgenic mouse models of tauopathy by examining the two main isolation methods sarkosyl and formic acid extraction.

The Uses of N,N'-Methylenebisacrylamide

Organic intermediate, cross-linking agent.

The Uses of N,N'-Methylenebisacrylamide

N,N-Methylene-bis-acrylamide is an organic intermediate; cross-linking agent for preparation of polyacrylamides; in preparing poly-acrylamide gel for e1ectrophoresis, chemical grouting and other purposes; in NAPP and Nyloprint UV-cured printing plates.

What are the applications of Application

N,N′-Methylenebis-Acrylamide, 2% is a preparatory agent for polyacrylamide gels

What are the applications of Application

N,N′-Methylenebis-Acrylamide is a preparatory agent for polyacrylamide gels

General Description

White crystalline powder with a neutral odor.

Air & Water Reactions

Very slightly water soluble.

Reactivity Profile

N,N'-Methylenebisacrylamide is incompatible with strong oxidizers, strong acids and strong bases.

Hazard

Toxic by ingestion.

Fire Hazard

Flash point data for N,N'-Methylenebisacrylamide are not available; however, N,N'-Methylenebisacrylamide is probably combustible.

Safety Profile

Poison by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Recrystallise the amide from MeOH (100g dissolved in 500mL boiling MeOH) and filter without suction in a warmed funnel. Allow to stand at room temperature and then at -15oC overnight. The crystals are collected with suction in a cooled funnel and washed with cold MeOH. The crystals are air-dried in a warm oven. [Beilstein 2 IV 1472.] VERY TOXIC (neurotoxic).

Properties of N,N'-Methylenebisacrylamide

Melting point:	>300 °C(lit.)
Boiling point:	277.52°C (rough estimate)
Density	1.235
vapor density	5.31 (vs air)
vapor pressure	0-0.073Pa at 20-84.85℃
refractive index	1.4880 (estimate)
storage temp.	2-8°C
solubility	H₂O: 20 mg/mL at 20 °C, clear, colorless
form	powder
pka	13.07±0.46(Predicted)
color	White
Odor	Odorless
PH Range	>5
PH	>=5.0 (25g/l, H2O, 20℃)
Water Solubility	0.01-0.1 g/100 mL at 18 ºC
Sensitive	Air & Light Sensitive
λmax	528nm(H2O)(lit.)
BRN	1706297
Stability:	Light Sensitive
CAS DataBase Reference	110-26-9(CAS DataBase Reference)
NIST Chemistry Reference	2-Propenamide, n,n'-methylenebis-(110-26-9)
EPA Substance Registry System	N,N'-Methylenebisacrylamide (110-26-9)

Safety information for N,N'-Methylenebisacrylamide

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H301:Acute toxicity,oral H340:Germ cell mutagenicity
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up.