N-Fmoc-8-Aminooctanoic acid
Synonym(s):8-(Fmoc-amino)caprylic acid;8-(Fmoc-amino)octanoic acid
- CAS NO.：126631-93-4
- Empirical Formula: C23H27NO4
- Molecular Weight: 381.46
- MDL number: MFCD00235890
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is N-Fmoc-8-Aminooctanoic acid?
Description
N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical properties
White powder
Properties of N-Fmoc-8-Aminooctanoic acid
| Melting point: | 118-119 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4)) |
| Boiling point: | 597.7±33.0 °C(Predicted) |
| Density | 1.174±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | Powder |
| pka | 4.77±0.10(Predicted) |
| color | White |
| BRN | 8286497 |
| CAS DataBase Reference | 126631-93-4(CAS DataBase Reference) |
Safety information for N-Fmoc-8-Aminooctanoic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-Fmoc-8-Aminooctanoic acid
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