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HomeProduct name listN-DESMETHYLCLOZAPINE

N-DESMETHYLCLOZAPINE

Synonym(s):8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazepine;Norclozapine;Normethylclozapine

  • CAS NO.:6104-71-8
  • Empirical Formula: C17H17ClN4
  • Molecular Weight: 312.8
  • MDL number: MFCD00210189
  • EINECS: 636-421-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-09 19:38:33
N-DESMETHYLCLOZAPINE Structural

What is N-DESMETHYLCLOZAPINE?

Chemical properties

Yellow Crystalline Solid

The Uses of N-DESMETHYLCLOZAPINE

N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients.

The Uses of N-DESMETHYLCLOZAPINE

A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.

The Uses of N-DESMETHYLCLOZAPINE

A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist.

What are the applications of Application

N-Desmethylclozapine is a metabolite of clozapine and neurotransmitter

Definition

ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.

General Description

N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril? and FrazaClo in the US. This Certified Snap-N-Spike? Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.

Biological Activity

A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist.

Biochem/physiol Actions

N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors.

storage

Room temperature

Properties of N-DESMETHYLCLOZAPINE

Melting point: 120-125°C
Boiling point: 502.6±60.0 °C(Predicted)
Density  1.38±0.1 g/cm3(Predicted)
Flash point: 9℃
storage temp.  Store at RT
solubility  Chloroform (Slightly), DMSO, Methanol (Slightly)
form  Yellow solid.
pka 8.49±0.10(Predicted)
color  Light Yellow to Yellow
CAS DataBase Reference 6104-71-8(CAS DataBase Reference)

Safety information for N-DESMETHYLCLOZAPINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for N-DESMETHYLCLOZAPINE

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