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HomeProduct name listN-Acetylglycine

N-Acetylglycine

Synonym(s):Acetamidoacetic acid;Aceturic acid

  • CAS NO.:543-24-8
  • Empirical Formula: C4H7NO3
  • Molecular Weight: 117.1
  • MDL number: MFCD00004275
  • EINECS: 208-839-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-06 15:28:16
N-Acetylglycine Structural

What is N-Acetylglycine?

Chemical properties

white to light yellow crystal powde

The Uses of N-Acetylglycine

N-Acetyl-glycine is a derivative of Glycine (G615990). It is an intermediate used to synthesize rac 3-O-Methyl DOPA (M303805) which is an impurity of Levodopa.

Definition

ChEBI: An N-acylglycine where the acyl group is specified as acetyl.

Description

N-acetylglycine is used is in biological research of peptidomimetics. It is used as the blocking agent of the N-terminus to prepare unnatural and unusual amino acids and amino acid analogs as well as to modify peptides. N-Substituted glycine analogs are widely used in peptidomimetics and drug research.

Preparation

Aceturic acid can be prepared by warming glycine either with a slight excess of acetic anhydride in benzene, or with an equal molar amount of acetic anhydride in glacial (concentrated) acetic acid.

Purification Methods

N-Acetylglycine is treated with acid-washed charcoal and recrystallised three times from water or EtOH/Et2O and is dried in vacuo over KOH [King & King J Am Chem Soc 78 1089 1956]. [Beilstein 4 IV 2399.]

Properties of N-Acetylglycine

Melting point: 207-209 °C (lit.)
Boiling point: 218.88°C (rough estimate)
Density  1.3886 (rough estimate)
refractive index  1.4540 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  26.3g/l
form  Crystalline Powder
pka 3.669(at 25℃)
color  White
Water Solubility  2.7 g/100 mL (15 ºC)
Merck  14,80
BRN  774114
CAS DataBase Reference 543-24-8(CAS DataBase Reference)
NIST Chemistry Reference Glycine, N-acetyl-(543-24-8)
EPA Substance Registry System Glycine, N-acetyl- (543-24-8)

Safety information for N-Acetylglycine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for N-Acetylglycine

InChIKey OKJIRPAQVSHGFK-UHFFFAOYSA-N

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