N-Acetyl-L-glutamic acid
- CAS NO.:1188-37-0
- Empirical Formula: C7H11NO5
- Molecular Weight: 189.17
- MDL number: MFCD00002802
- EINECS: 214-708-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is N-Acetyl-L-glutamic acid?
Chemical properties
white crystalline powder
The Uses of N-Acetyl-L-glutamic acid
N-Acetyl-L-glutamic Acid is the N-Acetyl analogue of the non-essential amino acid, L-glutamic acid (G596960). N-Acetyl-L-glutamic Acid activates carbamoyl phosphate synthetase in the urea cycle.
The Uses of N-Acetyl-L-glutamic acid
Substrate for acetylglutamate kinase. Inhibitor of N-acetyl-L-glutamate synthetase
The Uses of N-Acetyl-L-glutamic acid
N-Acetyl-L-glutamic acid is used as pharmaceutical intermediates.
Definition
ChEBI: N-acetyl-L-glutamic acid is an N-acyl-L-amino acid that is L-glutamic acid in which one of the amine hydrogens is substituted by an acetyl group. It has a role as a Saccharomyces cerevisiae metabolite and a human metabolite. It is a N-acetyl-L-amino acid and a N-acyl-L-glutamic acid. It is functionally related to a L-glutamic acid. It is a conjugate acid of a N-acetyl-L-glutamate(1-).
Purification Methods
A likely impurity is glutamic acid. Crystallise it from boiling water. It inhibits N-acetyl-L-glutamate synthase. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1948 1961, Shigesada & Tatibana Eur J Biochem 84 285 1978, Coude Biochem Biophys Res Commun 102 1016 1981, Beilstein 4 IV 3047.]
Properties of N-Acetyl-L-glutamic acid
Melting point: | 194-196 °C(lit.) |
Boiling point: | 324.41°C (rough estimate) |
alpha | -16 º (c=1, water) |
Density | 1.4119 (rough estimate) |
refractive index | -15 ° (C=1, H2O) |
FEMA | 4752 | N-ACETYL GLUTAMATE |
storage temp. | 2-8°C |
solubility | 36g/l (Lit.) |
form | Solid |
pka | 3.45±0.10(Predicted) |
color | White |
optical activity | [α]22/D 15.6°, c = 1 in H2O |
Water Solubility | 2.7 g/100 mL (20 ºC) |
BRN | 1727473 |
CAS DataBase Reference | 1188-37-0(CAS DataBase Reference) |
NIST Chemistry Reference | N-acetyl-l-glutamic acid(1188-37-0) |
EPA Substance Registry System | L-Glutamic acid, N-acetyl- (1188-37-0) |
Safety information for N-Acetyl-L-glutamic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for N-Acetyl-L-glutamic acid
Abamectin manufacturer
TEADUS PHARMA PRIVATE LIMITED
SV CHEM INTERMEDITES PRIVATE LIMITED
JSK Chemicals
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