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HomeProduct name listN-Acetyl-L-glutamic acid

N-Acetyl-L-glutamic acid

  • CAS NO.:1188-37-0
  • Empirical Formula: C7H11NO5
  • Molecular Weight: 189.17
  • MDL number: MFCD00002802
  • EINECS: 214-708-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-20 11:41:24
N-Acetyl-L-glutamic acid Structural

What is N-Acetyl-L-glutamic acid?

Chemical properties

white crystalline powder

The Uses of N-Acetyl-L-glutamic acid

N-Acetyl-L-glutamic Acid is the N-Acetyl analogue of the non-essential amino acid, L-glutamic acid (G596960). N-Acetyl-L-glutamic Acid activates carbamoyl phosphate synthetase in the urea cycle.

The Uses of N-Acetyl-L-glutamic acid

Substrate for acetylglutamate kinase. Inhibitor of N-acetyl-L-glutamate synthetase

The Uses of N-Acetyl-L-glutamic acid

N-Acetyl-L-glutamic acid is used as pharmaceutical intermediates.

Definition

ChEBI: N-acetyl-L-glutamic acid is an N-acyl-L-amino acid that is L-glutamic acid in which one of the amine hydrogens is substituted by an acetyl group. It has a role as a Saccharomyces cerevisiae metabolite and a human metabolite. It is a N-acetyl-L-amino acid and a N-acyl-L-glutamic acid. It is functionally related to a L-glutamic acid. It is a conjugate acid of a N-acetyl-L-glutamate(1-).

Purification Methods

A likely impurity is glutamic acid. Crystallise it from boiling water. It inhibits N-acetyl-L-glutamate synthase. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1948 1961, Shigesada & Tatibana Eur J Biochem 84 285 1978, Coude Biochem Biophys Res Commun 102 1016 1981, Beilstein 4 IV 3047.]

Properties of N-Acetyl-L-glutamic acid

Melting point: 194-196 °C(lit.)
Boiling point: 324.41°C (rough estimate)
alpha  -16 º (c=1, water)
Density  1.4119 (rough estimate)
refractive index  -15 ° (C=1, H2O)
FEMA  4752 | N-ACETYL GLUTAMATE
storage temp.  2-8°C
solubility  36g/l (Lit.)
form  Solid
pka 3.45±0.10(Predicted)
color  White
optical activity [α]22/D 15.6°, c = 1 in H2O
Water Solubility  2.7 g/100 mL (20 ºC)
BRN  1727473
CAS DataBase Reference 1188-37-0(CAS DataBase Reference)
NIST Chemistry Reference N-acetyl-l-glutamic acid(1188-37-0)
EPA Substance Registry System L-Glutamic acid, N-acetyl- (1188-37-0)

Safety information for N-Acetyl-L-glutamic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for N-Acetyl-L-glutamic acid

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