Ethyl 3-(pyridin-2-ylamino)propanoate
- CAS NO.：103041-38-9
- Empirical Formula: C10H14N2O2
- Molecular Weight: 194.23
- MDL number: MFCD09833621
- EINECS: 600-382-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is Ethyl 3-(pyridin-2-ylamino)propanoate?
Chemical properties
White Solid
The Uses of Ethyl 3-(pyridin-2-ylamino)propanoate
Ethyl 3-(2-Pyridylamino)propanoate is an intermediate used in the synthesis of Dabigatran etexilate, as thrombin inhibitors. Ethyl Ester form of P993315.
Synthesis
A method for preparing Ethyl 3-(pyridin-2-ylamino)propanoate comprises the following steps: using 2-aminopyridine and ethyl acrylate as raw materials, using anhydrous ethanol as a solvent, using trifluoromethanesulfonic acid as a catalyst, and heating in an oil bath to control the temperature at 120 to 160° C. for a catalytic reaction for 16 to 20 hours under nitrogen protection. The obtained reaction solution is washed with petroleum ether at a temperature of 35 to 40° C. and a pressure of 0.09 to 0.1 MPa, then concentrated under reduced pressure, and then washed with petroleum ether/ethyl acetate and recrystallized to obtain white flaky crystals of Ethyl 3-(pyridin-2-ylamino)propanoate.
Properties of Ethyl 3-(pyridin-2-ylamino)propanoate
| Melting point: | 48-50°C |
| Boiling point: | 125°C/0.2mmHg(lit.) |
| Density | 1.131±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | 6.26±0.10(Predicted) |
| color | White |
| InChI | InChI=1S/C10H14N2O2/c1-2-14-10(13)6-8-12-9-5-3-4-7-11-9/h3-5,7H,2,6,8H2,1H3,(H,11,12) |
Safety information for Ethyl 3-(pyridin-2-ylamino)propanoate
Computed Descriptors for Ethyl 3-(pyridin-2-ylamino)propanoate
| InChIKey | UITNIDFEANEWPC-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)CCNC1C=CC=CN=1 |
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