ERK Inhibitor
Synonym(s):3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl;ERK Inhibitor - CAS 1049738-54-6 - Calbiochem
- CAS NO.:1049738-54-6
- Empirical Formula: C14H17ClN2O3S
- Molecular Weight: 328.81
- MDL number: MFCD09038681
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 21:39:59
What is ERK Inhibitor?
Description
ERK inhibitor is a cell-
What are the applications of Application
ERK Inhibitor is a cell-permeable thiazolidinedione compound that shows anti-proliferative properties
General Description
A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 μM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.
Biochem/physiol Actions
Primary TargetERK
Properties of ERK Inhibitor
storage temp. | +2C to +8C |
solubility | DMSO: 2 mg/ml |
form | Light yellow solid |
color | Off-white to yellow |
Safety information for ERK Inhibitor
Computed Descriptors for ERK Inhibitor
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