MOPSO

Synonym(s):β-Hydroxy-4-morpholinepropanesulfonic acid;3-Morpholino-2-hydroxypropanesulfonic acid;MOPSO

CAS NO.：68399-77-9
Empirical Formula: C7H15NO5S
Molecular Weight: 225.26
MDL number: MFCD00009629
EINECS: 269-989-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-25 16:21:11

What is MOPSO?

Description

MOPSO Free Acid is a zwitterionic aminosulfonate buffer with a similar structure to MOPS and a useful pH range of 6.5 - 7.9. It may be used as a buffer component in various biological applications including DNA gel electrophoresis. It has been found that MOPSO buffer combined excellent pH stabilization at pH 7·00 and limited color alteration by testing the color changes of raw sugar solutions so that MOPSO buffer and three glass-fiber filters in series can be used to reduce the effect of pH and turbidity on color measurement of raw sugar solution[1]. The activity of the endo-α-D-mannosidase enzyme in MOPSO buffers at pH 7.0 is increased very much over buffers like HEPES or HEPPS. This buffer also has been employed as a buffer component of charcoal yeast extract medium[2]. However, morpholine family buffers (MES, MOPS, and MOPSO) have been reported to interact with the trivalent metal ions Cr³⁺ and Fe³⁺. Therefore, extensive testing is required before using MAPSO.

Chemical properties

white crystalline powder

The Uses of MOPSO

MOPSO is a buffer that works in the 6-7 pH range. Used in pharmaceutical synthesis.

The Uses of MOPSO

MOPSO is a biological buffer also referred to as a second generation “Good′s” buffer which displays improved solubility compared to traditional “Good′s” buffers. The pKa of MOPSO is 6.9 which make it an ideal candidate for buffer formulations which require a pH slightly below physiological to maintain a stable environment in solution. MOPSO is considered to be non-toxic to culture cell lines and provides high-solution clarity.

MOPSO can be used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream) and diagnostic reagents.

What are the applications of Application

MOPSO Free Acid is a zwitterionic aminosulfonate buffer similar to MOPS, pH range: 6.5 - 7.9

Definition

ChEBI: 3-(n-morpholino)-2-hydroxypropanesulfonic acid is a member of morpholines.

References

[1] Ahmedna M, et al. Use of filtration and buffers in raw sugar colour measurements. Journal of the Science of Food and Agriculture, 1997; 75: 109-116.
[2] Taha M, et al. Interactions of Biological Buffers with Macromolecules: The Ubiquitous “Smart” Polymer PNIPAM and the Biological Buffers MES, MOPS, and MOPSO. Macromolecules, 2011; 44: 8575–858.

Properties of MOPSO

Melting point:	275-280 °C (dec.)
Density	1.416±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	H₂O: 0.5 M at 20 °C, clear
form	Crystalline Powder
pka	pK1:6.75 (37°C)
color	White
Odor	Odorless
PH Range	6.2 - 7.6
Water Solubility	Water solubility under desired conditions ca.112,6 g/L at 20°C.
BRN	1109697
InChI	InChI=1S/C7H15NO5S/c9-7(6-14(10,11)12)5-8-1-3-13-4-2-8/h7,9H,1-6H2,(H,10,11,12)
CAS DataBase Reference	68399-77-9(CAS DataBase Reference)
EPA Substance Registry System	4-Morpholinepropanesulfonic acid, .beta.-hydroxy- (68399-77-9)

Safety information for MOPSO

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.