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HomeProduct name list3-Amino-1-propanesulfonic acid

3-Amino-1-propanesulfonic acid

Synonym(s):3-Amino-1-propanesulfonic acid;3APS;Acamprosate Calcium Impurity A (PhEur);Homotaurine;Tramiprosate

  • CAS NO.:3687-18-1
  • Empirical Formula: C3H9NO3S
  • Molecular Weight: 139.17
  • MDL number: MFCD00008225
  • EINECS: 222-977-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
3-Amino-1-propanesulfonic acid Structural

What is 3-Amino-1-propanesulfonic acid?

Description

Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.

Chemical properties

White Powder

The Uses of 3-Amino-1-propanesulfonic acid

3-Amino-1-propanesulfonic acid is a Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA). It is an intermediate in the synthesis of acamprosate. acamprosate is an alcohol addiction treatment commonly used to reduce urges to drink and help people in recovery remain sober.

What are the applications of Application

Tramiprosate is a sulfated glycosaminoglycan mimic that targets amyloid β

Definition

ChEBI: 3-Aminopropanesulfonate is an organosulfonic acid.

Biological Activity

Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo .

Properties of 3-Amino-1-propanesulfonic acid

Melting point: 293 °C (dec.)(lit.)
Density  1.202 (estimate)
refractive index  1.5130 (estimate)
storage temp.  2-8°C
solubility  Water (Slightly)
pka 1.06±0.50(Predicted)
form  Crystalline Powder
color  White to slightly blue
CAS DataBase Reference 3687-18-1(CAS DataBase Reference)

Safety information for 3-Amino-1-propanesulfonic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 3-Amino-1-propanesulfonic acid

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