ML167
Synonym(s):5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol;CID 44968231;NCGC00188654
- CAS NO.：1285702-20-6
- Empirical Formula: C19H17N3O3
- Molecular Weight: 335.36
- MDL number: MFCD27978379
- EINECS: 808-432-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-15 19:19:13
What is ML167?
Description
ML167 (1285702-20-6) is a highly selective cell permeable inhibitor of Cdc2-like kinase 4 (Clk4) – IC50?= 136nM. It displays at least 10-fold greater selectivity over the related kinases Clk1(1.52 μM), Clk2(1.65μM), Clk3(>10μM), Dyrk1A(>10μM), and Dyrk1B(4.4 μM).
Definition
ChEBI: [5-[4-[(5-methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol is a member of quinazolines.
References
1) Rosenthal?et al. (2010),?An inhibitor of the Cdc2-like kinase 4 (Clk4); Probe Reports from the NIH Molecular Libraries Program
Properties of ML167
| Boiling point: | 531.8±45.0 °C(Predicted) |
| Density | 1.335±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| pka | 13.84±0.10(Predicted) |
| color | off-white to gray to brown |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Safety information for ML167
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ML167
New Products
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