ML-7 HYDROCHLORIDE
Synonym(s):1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl;ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem
- CAS NO.:110448-33-4
- Empirical Formula: C15H18ClIN2O2S
- Molecular Weight: 452.74
- MDL number: MFCD00065524
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is ML-7 HYDROCHLORIDE?
Description
ML-
Chemical properties
Off-White to Yellow Fine Crystalline Solid
The Uses of ML-7 HYDROCHLORIDE
A potent and selective inhibitor of myosin light chain kinase.
The Uses of ML-7 HYDROCHLORIDE
ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.
What are the applications of Application
ML-7 hydrochloride is an inhibitor of MYLK, PKC, and PKA
Biochem/physiol Actions
Selective myosin light chain kinase inhibitor.
in vitro
rats with myocardial infarction were intravenously infused with rhnrg-1. the cmlck expression and phosphorylated mlc-2v were up-regulated in rat treated with rhnrg-1 significantly. moreover, the restoration of rhnrg-1-induced sarcomeric organization in serum-free cultured neonatal rat cardiomyocytes with rhnrg-1 was inhibited by ml-7 [1].
in vivo
administration of ml-7 from 10 min before ischemia to the first 10 min of reperfusion led to a significant recovery of heart contractility. gel analyses of two-dimensional electrophoresis revealed eight proteins with decreased levels in i/r hearts. six proteins involved in energy metabolism, which were cytochrome b-c1 complex subunit 1, atp synthase beta subunit, cytochrome c oxidase subunit, mitochondrial nadhdehydrogenase, nadhdehydrogenase iron-sulfur protein 8, and succinyl-coa ligase subunit. the other two protein levels decreased in i/r hearts, which were peroxiredoxin-2 and tubulin. in addition, ml-7 treatment increased the level of succinyl-coa ligase, which was a key enzyme involved in the citric acid cycle [2].
storage
room temperature (desiccate)
References
[1] gu x,liu x,xu d,li x,yan m,qi y,yan w,wang w,pan j,xu y,xi b,cheng l,jia j,wang k,ge j,zhou m. cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin. cardiovasc res.2010 nov 1;88(2):334-43.
[2] lin hb,cadete vj,sawicka j,wozniak m,sawicki g. effect of the myosin light chain kinase inhibitor ml-7 on the proteome of hearts subjected to ischemia-reperfusion injury. j proteomics.2012 sep 18;75(17):5386-95.
Properties of ML-7 HYDROCHLORIDE
Melting point: | 246-249°C dec. |
storage temp. | -20°C |
solubility | insoluble in EtOH; ≥15.95 mg/mL in DMSO; ≥8.82 mg/mL in H2O with gentle warming and ultrasonic |
form | powder |
color | white |
Safety information for ML-7 HYDROCHLORIDE
Computed Descriptors for ML-7 HYDROCHLORIDE
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