ML329
- CAS NO.：19992-50-8
- Empirical Formula: C16H12N2O4S
- Molecular Weight: 328.34
- MDL number: MFCD30579194
- EINECS: 604-604-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-13 18:13:23
What is ML329?
Definition
ChEBI: 4-[(1,4-dioxo-2-naphthalenyl)amino]benzenesulfonamide is a member of 1,4-naphthoquinones.
Biological Activity
ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor that inhibits TRPM-1 promoter activity with IC50 of 1.2 μM.
in vitro
ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. It could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with it will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. It shows specific activity against the MITF -dependent cells, primary melanocytes but no effect on the viability in A375 cells. It reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, it will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.
Properties of ML329
| storage temp. | 2-8°C(protect from light) |
| solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 0.1 mg/ml |
| form | A crystalline solid |
| color | White to off-white |
Safety information for ML329
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ML329
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-(dimethylamino)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one Iminostilbene 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN Diclofenac Sodium SODIUM VALPROATE Racecadotril XANTHAN GUM 5-Fluoro-2-iodo-3-methylphenol 4-(Cyanomethyl)-1-piperidineacetamide 6-Bromo-2-iodo-4-methyl-3-pyridinamine 5-Amino-3-bromo-2-chlorobenzeneacetic acidRelated products of tetrahydrofuran
![[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone](https://img.chemicalbook.in/CAS/20180629/GIF/1360705-96-9.gif)
You may like
-
1823754-06-8 98%View Details
1823754-06-8 -
1935373-20-8 3-(Bromomethyl)-6-fluoro-1,2-benzenediamine 98%View Details
1935373-20-8 -
2-Chloro-5-(iodomethyl)pyrimidine 2268818-88-6 98%View Details
2268818-88-6 -
2092793-98-9 98%View Details
2092793-98-9 -
1360944-55-3 7-Methoxy-1H-indol-5-amine 98%View Details
1360944-55-3 -
2090480-14-9 98%View Details
2090480-14-9 -
1-Methyl 2-bromo-5-[(1-carboxy-1-methylethyl)amino]benzoate 1651844-56-2 98%View Details
1651844-56-2 -
176445-77-5 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 98+View Details
176445-77-5