ML329
- CAS NO.:19992-50-8
- Empirical Formula: C16H12N2O4S
- Molecular Weight: 328.34
- MDL number: MFCD30579194
- EINECS: 604-604-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:03
What is ML329?
Definition
ChEBI: 4-[(1,4-dioxo-2-naphthalenyl)amino]benzenesulfonamide is a member of 1,4-naphthoquinones.
Biological Activity
ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor that inhibits TRPM-1 promoter activity with IC50 of 1.2 μM.
in vitro
ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. It could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with it will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. It shows specific activity against the MITF -dependent cells, primary melanocytes but no effect on the viability in A375 cells. It reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, it will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.
Properties of ML329
storage temp. | 2-8°C(protect from light) |
solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 0.1 mg/ml |
form | A crystalline solid |
color | White to off-white |
Safety information for ML329
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ML329
New Products
6-Bromo 2-Iodo Indole Ivermectin EP Impurity B Rimegepant Impurity 3 Fosfomycin EP impurity D Tubulysin G Tubulysin F 2,2-diethoxyethanethioamide Tubulysin D Potassium HMDS (1.0 M in THF) Calcium Sodium Phosphosilicate IH Fuel shell (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 4,7-Dibromobenzo[c][1,2,5]thiadiazole-5,6-diamine 2-Chloro-3-(chloromethyl)pyridine 4-Bromo-N,N-bis(4-iodophenyl)aniline (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate Methyl 4-amino-3-(pyrrolidin-1-yl)benzoate 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 7-(1,1-Dimethylethyl) 7-azaspiro[3.5]nonane-2,7-dicarboxylate 4,6-difluoro-1H-indole (2S,4R)-4-((tert-butoxycarbonyl)amino)-5-(4-hydroxyphenyl)-2-methylpentanoic acidRelated products of tetrahydrofuran
You may like
-
3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dioneView Details
952145-70-9 -
452-58-4View Details
452-58-4 -
1262243-12-8View Details
1262243-12-8 -
65195-56-4View Details
65195-56-4 -
Rimegepant Impurity 3View Details
-
Sidchem 730View Details
-
Sidchem BT 20View Details
-
1572177-89-9View Details
1572177-89-9