MIF Antagonist, ISO-1
Synonym(s):;(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Macrophage Migration Inhibitory Factor Antagonist, ISO-1;InSolution MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem;MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem
- CAS NO.:478336-92-4
- Empirical Formula: C12H13NO4
- Molecular Weight: 235.24
- MDL number: MFCD22376813
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is MIF Antagonist, ISO-1?
Description
ISO-1 (478336-92-4) is an antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis.1 Inhibits airway remodeling in mouse asthma model.2 ISO-1 also blocks MIF-induced autophagy.3?Active in cellular and mouse models.
The Uses of MIF Antagonist, ISO-1
MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 μM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. MIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.
What are the applications of Application
MIF Antagonist, ISO-1 is a cell-permeable isoxazoline compound that displays anti-inflammatory properties
storage
Store at +4°C
References
1) Al-Abed et al. (2005), ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis; J. Biol. Chem., 280 2) Chen et al. (2010), ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma; Mol. Med., 16 400 3) Chuang et al. (2012), Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation; PLoS One, 7 e37613
Properties of MIF Antagonist, ISO-1
Melting point: | 114 °C |
Boiling point: | 365.0±48.0 °C(Predicted) |
Density | 1.30±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
solubility | Soluble in DMSO. |
pka | 9.22±0.30(Predicted) |
form | Light yellow crystalline solid. |
color | Off-white |
Sensitive | Light Sensitive |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
Safety information for MIF Antagonist, ISO-1
Computed Descriptors for MIF Antagonist, ISO-1
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