Mezlocillin sodium
- CAS NO.:59798-30-0
- Empirical Formula: C22H27N6NaO9S2
- Molecular Weight: 606.6
- MDL number: MFCD07793332
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-29 22:41:02
What is Mezlocillin sodium?
Description
Mezlocillin is a β-lactam antibiotic and derivative of ampicillin . It is active against B. fragilis, E. lentum, P. morbillorum, and F. nucleatum (MICs = 8, 4, 2, and 4 μg/ml, respectively). Mezlocillin (32 μg/ml) is also active against 10 strains of S. faecalis. In vivo, mezlocillin (240 mg/kg) increases survival and reduces bacteremia in a rabbit model of S. faecalis endocarditis. It completely eliminates lung P. morbillorum, E. lentum, and F. nucelatum, but not B. fragilis, in a rabbit model of pulmonary P. morbillorum, E. lentum, F. nucelatum, and B. fragilis infection when administered at a dose of 300 mg/kg. Formulations containing mezlocillin have been used in the treatment of various bacterial infections.
Chemical properties
Mezlocillin sodium is white to slightly yellow cryst. powder
The Uses of Mezlocillin sodium
Mezlocillin Sodium (cas# 59798-30-0) is a derivative of penicillin and an antimicrobial.
The Uses of Mezlocillin sodium
Antibacterial.
Definition
ChEBI: Mezlocillin sodium is an organic sodium salt. It contains a mezlocillin(1-).
brand name
Mezlin (Bayer).
Clinical Use
Mezlocillin (Mezlin) is an acylureidopenicillin with an antibacterialspectrum similar to that of carbenicillin andticarcillin; however, there are some major differences. It ismuch more active against most Klebsiella spp., P. aeruginosa,anaerobic bacteria (e.g., Streptococcus faecalis andB. fragilis), and H. influenzae. It is recommended for thetreatment of serious infections caused by these organisms.
Mezlocillin is not generally effective against β-lactamase–producing bacteria, nor is it active orally. It isavailable as a white, crystalline, water-soluble sodium saltfor injection. Solutions should be prepared freshly and, ifnot used within 24 hours, refrigerated. Mezlocillin and otheracylureidopenicillins, unlike carbenicillin, exhibit nonlinearpharmacokinetics. Peak plasma levels, half-life, and areaunder the time curve increase with increased dosage.Mezlocillin has less effect on bleeding time than carbenicillin,and it is less likely to cause hypokalemia.
Properties of Mezlocillin sodium
Melting point: | 197-201°C (dec.) |
storage temp. | Refrigerator |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
color | White to Off-White |
Water Solubility | Soluble in water or DMSO |
CAS DataBase Reference | 59798-30-0(CAS DataBase Reference) |
Safety information for Mezlocillin sodium
Computed Descriptors for Mezlocillin sodium
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