Methylbutyric acid
- CAS NO.：600-07-7
- Empirical Formula: C5H10O2
- Molecular Weight: 102.13
- MDL number: MFCD00002669
- EINECS: 204-145-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:40
What is Methylbutyric acid?
Chemical properties
Colorless liquid. The boiling point is 177°C, 84°C (2.8kPa), the relative density (20/17°C) is 0.938, and the refractive index (nD20) is 1.4055. Soluble in water, ethanol, ether.
The Uses of Methylbutyric acid
Methylbutyric acid can be used as an organic synthesis intermediate.
Definition
ChEBI: 2-methylbutyric acid is a methylbutyric acid comprising a butyric acid core carrying a 2-methyl substituent. Produced from amino acid leucine during nutrient starvation in bacteria. It has a role as a bacterial metabolite and a human metabolite. It is a conjugate acid of a 2-methylbutyrate.
Synthesis
2-Chlorobutane is made into Grignard reagent, which is then reacted with carbon dioxide, and the reaction mixture is hydrolyzed with 25% sulfuric acid to generate Methylbutyric acid. Yield 76-86%.
Properties of Methylbutyric acid
| Melting point: | -70°C |
| Boiling point: | 176-177 °C(lit.) |
| Density | 0.936 g/mL at 25 °C(lit.) |
| vapor pressure | 0.5 mm Hg ( 20 °C) |
| refractive index | n |
| FEMA | 2695 | 2-METHYLBUTYRIC ACID |
| Flash point: | 165 °F |
| pka | 4.8(at 25℃) |
| CAS DataBase Reference | 600-07-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Methylbutyric acid(600-07-7) |
| EPA Substance Registry System | Butanoic acid, 2-methyl-(600-07-7) |
Safety information for Methylbutyric acid
Computed Descriptors for Methylbutyric acid
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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