Methylaminoacetaldehyde dimethyl acetal
Synonym(s):(Methylamino)acetaldehyde dimethyl acetal;1,1-Dimethoxy-2-methylaminoethane;2,2-Dimethoxy-N-methylethylamine
- CAS NO.:122-07-6
- Empirical Formula: C5H13NO2
- Molecular Weight: 119.16
- MDL number: MFCD00008485
- EINECS: 204-520-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:30
What is Methylaminoacetaldehyde dimethyl acetal?
Description
Methylaminoacetaldehyde dimethyl acetal can be used as a pharmaceutical synthesis intermediate, such as the preparation of methimazole, the chemical name is 1-methylimidazole-2-thiol, which is an antithyroid drug, and its mechanism of action is to inhibit thyroid endoperoxide Enzymes, thereby hindering the oxidation of iodide absorbed into the thyroid and the coupling of tyrosine, hindering the synthesis of thyroxine (T4) and triiodothyronine (T3). Animal experiments have observed that B lymphocytes synthesize antibodies, reduce the level of thyroid-stimulating antibodies in the blood circulation, and restore the suppressor T cells to normal.
Chemical properties
clear colorless to light yellowish liquid
The Uses of Methylaminoacetaldehyde dimethyl acetal
2,2-Dimethoxy-N-methylethanamine is an impurity formed in the synthetic process of Methimazole (M260300), a thiourea antithyroid agent that prevents iodine organification,
The Uses of Methylaminoacetaldehyde dimethyl acetal
(Methylamino)acetaldehyde dimethyl acetal can be used as a reactant to synthesize:
- Aza[3.3.2] cyclazines by reacting with 5-methyloxazolo[3,2-a]pyridinium salts via synthesis of functionalized 5-aminoindolizines intermediates.
- N-(2,2-Dimethoxyethyl)-N-methyl-3,4-dimethoxyphenylglycine by Petasis reaction with glyoxylic acid and 3,4-dimethoxyphenylboronic acid.
- Substituted imidazoles via copper-catalyzed reaction with various nitriles.
Properties of Methylaminoacetaldehyde dimethyl acetal
Melting point: | -73°C |
Boiling point: | 140 °C (lit.) |
Density | 0.928 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | 85 °F |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
pka | 8.29±0.20(Predicted) |
form | liquid &_& neat |
color | Colorless to Light yellow to Light orange |
PH | 10.9 (10g/l, H2O, 20℃) |
Water Solubility | miscible |
Sensitive | Air Sensitive |
BRN | 605322 |
CAS DataBase Reference | 122-07-6(CAS DataBase Reference) |
NIST Chemistry Reference | Ethanamine, 2,2-dimethoxy-N-methyl-(122-07-6) |
EPA Substance Registry System | Ethanamine, 2,2-dimethoxy-N-methyl- (122-07-6) |
Safety information for Methylaminoacetaldehyde dimethyl acetal
Signal word | Warning |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H226:Flammable liquids H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Methylaminoacetaldehyde dimethyl acetal
Methylaminoacetaldehyde dimethyl acetal manufacturer
Mana Pharma
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