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HomeProduct name listMethylaminoacetaldehyde dimethyl acetal

Methylaminoacetaldehyde dimethyl acetal

Synonym(s):(Methylamino)acetaldehyde dimethyl acetal;1,1-Dimethoxy-2-methylaminoethane;2,2-Dimethoxy-N-methylethylamine

  • CAS NO.:122-07-6
  • Empirical Formula: C5H13NO2
  • Molecular Weight: 119.16
  • MDL number: MFCD00008485
  • EINECS: 204-520-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:43:12
Methylaminoacetaldehyde dimethyl acetal Structural

What is Methylaminoacetaldehyde dimethyl acetal?

Description

Methylaminoacetaldehyde dimethyl acetal can be used as a pharmaceutical synthesis intermediate, such as the preparation of methimazole, the chemical name is 1-methylimidazole-2-thiol, which is an antithyroid drug, and its mechanism of action is to inhibit thyroid endoperoxide Enzymes, thereby hindering the oxidation of iodide absorbed into the thyroid and the coupling of tyrosine, hindering the synthesis of thyroxine (T4) and triiodothyronine (T3). Animal experiments have observed that B lymphocytes synthesize antibodies, reduce the level of thyroid-stimulating antibodies in the blood circulation, and restore the suppressor T cells to normal.

Chemical properties

clear colorless to light yellowish liquid

The Uses of Methylaminoacetaldehyde dimethyl acetal

2,2-Dimethoxy-N-methylethanamine is an impurity formed in the synthetic process of Methimazole (M260300), a thiourea antithyroid agent that prevents iodine organification,

The Uses of Methylaminoacetaldehyde dimethyl acetal

(Methylamino)acetaldehyde dimethyl acetal can be used as a reactant to synthesize:

  • Aza[3.3.2] cyclazines by reacting with 5-methyloxazolo[3,2-a]pyridinium salts via synthesis of functionalized 5-aminoindolizines intermediates.
  • N-(2,2-Dimethoxyethyl)-N-methyl-3,4-dimethoxyphenylglycine by Petasis reaction with glyoxylic acid and 3,4-dimethoxyphenylboronic acid.
  • Substituted imidazoles via copper-catalyzed reaction with various nitriles.

Properties of Methylaminoacetaldehyde dimethyl acetal

Melting point: -73°C
Boiling point: 140 °C (lit.)
Density  0.928 g/mL at 25 °C (lit.)
refractive index  n20/D 1.414(lit.)
Flash point: 85 °F
storage temp.  2-8°C
solubility  Chloroform (Slightly), Methanol (Slightly)
pka 8.29±0.20(Predicted)
form  liquid &_& neat
color  Colorless to Light yellow to Light orange
PH 10.9 (10g/l, H2O, 20℃)
Water Solubility  miscible
Sensitive  Air Sensitive
BRN  605322
CAS DataBase Reference 122-07-6(CAS DataBase Reference)
NIST Chemistry Reference Ethanamine, 2,2-dimethoxy-N-methyl-(122-07-6)
EPA Substance Registry System Ethanamine, 2,2-dimethoxy-N-methyl- (122-07-6)

Safety information for Methylaminoacetaldehyde dimethyl acetal

Signal word Warning
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H226:Flammable liquids
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Methylaminoacetaldehyde dimethyl acetal

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