Methyl pyruvate
Synonym(s):Pyruvic acid methyl ester
- CAS NO.:600-22-6
- Empirical Formula: C4H6O3
- Molecular Weight: 102.09
- MDL number: MFCD00008754
- EINECS: 209-987-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 13:32:20
What is Methyl pyruvate?
Chemical properties
Methyl pyruvate is a clear, light yellow, and flammable liquid.
The Uses of Methyl pyruvate
Methyl Pyruvate acts as a potent secretagogue used in the study of stimulus-secretion coupling. Also used in the preparation of quinoxalines as dual phoosphodiesterase 2/10 (PDE2/10) inhibitors. It increases free calcium ion concentration in the cytosol of pancreatic cells. It is used in the preparation of dimethyl 2,3-dimethylenebutanedioate.
The Uses of Methyl pyruvate
Methyl pyruvate may be used to investigate the adsorption and reactivity of methyl pyruvate on Pt{111}. It may be used in the preparation of dimethyl 2,3-dimethylenebutanedioate.
What are the applications of Application
Methyl pyruvate is a compound used in stimulus-secretion coupling
Definition
ChEBI: Methyl pyruvate is a pyruvate ester resultinf grom the formal condensation of the carboxy group of pyruvic acid with the hydroxy group of methanol. It is a pyruvate ester and a methyl ester. It derives from a pyruvic acid.
Preparation
Methyl pyruvate has been prepared from the silver salt of pyruvic acid and methyl iodide; from the free acid, by the ethanol-vapor method without a catalyst, by azeotropic removal of the water produced by the reaction of methanol in the presence of p-toluenesulfonic acid (the present method), and by refluxing with methanol in ethylene dichloride using ethanesulfonic acid as a catalyst (73% yield). Pyruvic esters have also been prepared by the catalytic dehydrogenation of lactic acid esters and by the oxidation of ethyl lactate with potassium permanganate.
DOI: 10.15227/orgsyn.024.0072
General Description
Methyl pyruvate is a pyruvic ester. Surface conditions during Pt/silica EUROPT-1 modified by cinchonidine catalyzed by enantioselective hydrogenation of methyl pyruvate to R-(+)-methyl lactate were investigated. Enantioselective hydrogenation of methyl pyruvate over finely dispersed polyvinylpyrrolidone-stabilized and the corresponding alumina-supported iridium clusters modified with cinchonidine was studied. The molecular orientation and conformation of methyl pyruvate on Ni(111) surface has been investigated in the temperature range 105-220K. Methyl pyruvate is reported to stimulate insulin secretion in vitro and in vivo.
Properties of Methyl pyruvate
Melting point: | -22 °C |
Boiling point: | 134-137 °C (lit.) |
Density | 1.13 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | 103 °F |
storage temp. | 2-8°C |
solubility | ethanol: soluble1.1g/10 mL, clear, colorless to almost colorless |
form | liquid |
color | Yellow |
Water Solubility | Soluble in chloroform, methanol, ether, alcohol. Slightly soluble in water. |
Merck | 14,8021 |
BRN | 1361953 |
CAS DataBase Reference | 600-22-6(CAS DataBase Reference) |
NIST Chemistry Reference | Propanoic acid, 2-oxo-, methyl ester(600-22-6) |
Safety information for Methyl pyruvate
Signal word | Warning |
Pictogram(s) |
Flame Flammables GHS02 |
GHS Hazard Statements |
H226:Flammable liquids |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. |
Computed Descriptors for Methyl pyruvate
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