Methyl diethylphosphonoacetate
Synonym(s):(Methoxycarbonylmethyl) diethoxyphosphine oxide;[(Methoxycarbonyl)methyl]phosphonic acid diethyl ester;Methyl P,P-diethylphosphonoacetate;NSC 147757
- CAS NO.：1067-74-9
- Empirical Formula: C7H15O5P
- Molecular Weight: 210.16
- MDL number: MFCD00009081
- EINECS: 213-938-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-25 23:13:37
What is Methyl diethylphosphonoacetate?
Chemical properties
Clear colorless to slightly yellow liquid
The Uses of Methyl diethylphosphonoacetate
Methyl diethylphosphonoacetate is used as a reagent in the preparation of allylic fluorides compounds and in regioselective Diels-Alder reactions. It also serves as a reactant in the preparation of substituted thiophenes and furans, which finds application in type 2 diabetes treatment. Further, it acts as a precursor in the synthesis of pyridone alkaloids and immunosuppressive cyclopentanediol derivatives. In addition to this, it is utilized in the modification of botulinum neurotoxin serotype A protease inhibitors.
Properties of Methyl diethylphosphonoacetate
| Boiling point: | 127-131 °C9 mm Hg(lit.) |
| Density | 1.145 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Miscible with tetrahydrofuran. |
| form | Liquid |
| color | Clear colorless to faint yellow |
| BRN | 1782397 |
| InChI | InChI=1S/C7H15O5P/c1-4-11-13(9,12-5-2)6-7(8)10-3/h4-6H2,1-3H3 |
| CAS DataBase Reference | 1067-74-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetic acid, phosphono-, p,p-diethyl c-methyl ester(1067-74-9) |
Safety information for Methyl diethylphosphonoacetate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Methyl diethylphosphonoacetate
| InChIKey | CTSAXXHOGZNKJR-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)CP(OCC)(OCC)=O |
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