Trimethyl phosphonoacetate
Synonym(s):(Carboxymethyl)phosphonic acid trimethyl ester;NSC 84262
- CAS NO.：5927-18-4
- Empirical Formula: C5H11O5P
- Molecular Weight: 182.11
- MDL number: MFCD00008452
- EINECS: 227-663-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-24 21:11:45
What is Trimethyl phosphonoacetate?
Chemical properties
clear colorless to light yellow liquid
The Uses of Trimethyl phosphonoacetate
Trimethyl phosphonoacetate is used in the preparation of sarin A by intramolecular Mannich-type reactions. It is involved in the Horner-Wadsworth-Emmons olefination with aldehydes and ketones to give acrylic esters. It is also involved in oxa-Michael reactions, prenylation of oxindoles and heterocyclization reactions.
What are the applications of Application
Trimethyl phosphonoacetate is an important Wittig-horner reagent, which can be used to manufacture important intermediates of natural compounds such as vitamins, drugs, insect pheromones, etc.
Reactant involved in:
Intramolecular Mannich-type reactions to produce the sarain A diazatricyclic core
Organocatalytic oxa-Michael reactions
Prenylation and geranylation of oxindoles
Intramolecular Horner-Wadsworth-Emmons reactions
Olefin cross-metathesis / heterocyclization
Definition
ChEBI: Trimethyl phosphonoacetate is a phosphonic ester.
Properties of Trimethyl phosphonoacetate
| Melting point: | 242 °C |
| Boiling point: | 118 °C0.85 mm Hg(lit.) |
| Density | 1.125 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Liquid |
| color | Clear colorless to light yellow |
| Specific Gravity | approximate 1.265ｇ/ml (20℃) |
| Water Solubility | Slightly miscible with water. |
| BRN | 1865177 |
| CAS DataBase Reference | 5927-18-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Trimethyl phosphonoacetate(5927-18-4) |
| EPA Substance Registry System | Acetic acid, (dimethoxyphosphinyl)-, methyl ester (5927-18-4) |
Safety information for Trimethyl phosphonoacetate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Trimethyl phosphonoacetate
Abamectin manufacturer
JSK Chemicals
1Y
Phone:+919879767970
Whatsapp: +91 9879767970
product: 5927-18-4 Trimethyl phosphonoacetate, 97% 99%
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
You may like
-
5927-18-4 Trimethyl phosphonoacetate, 97% 99%View Details
5927-18-4 -
5927-18-4 99%View Details
5927-18-4 -
Trimethyl phosphonoacetate 98% (GC) CAS 5927-18-4View Details
5927-18-4 -
Trimethyl phosphonoacetate CAS 5927-18-4View Details
5927-18-4 -
Trimethyl phosphono acetate CAS 5927-18-4View Details
5927-18-4 -
Trimethyl Phosphonoacetate CAS 5927-18-4View Details
5927-18-4 -
Trimethylphosphonoacetate CAS 5927-18-4View Details
5927-18-4 -
Trimethyl phosphonoacetate CAS 5927-18-4View Details
5927-18-4
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.