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HomeProduct name listMETHOXYRESORUFIN

METHOXYRESORUFIN

Synonym(s):7-Methoxy-3H-phenoxazin-3-one;Methoxyresorufin;O7-Methylresorufin

METHOXYRESORUFIN Structural

What is METHOXYRESORUFIN?

Description

Methoxyresorufin is a fluorogenic substrate for the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. Methyoxyresorufin is O-demethylated by CYP1A1/2, releasing resorufin, which displays excitation/emission maxima of 570/580 nm, respectively. The appearance of resorufin fluorescence can be used to quantify CYP1A1/2 activity.

The Uses of METHOXYRESORUFIN

Substrate for Cytochrome P-450. METHOXYRESORUFIN is used for various investigations including the differentiatiation of cytochrome P-450 isozymes.

The Uses of METHOXYRESORUFIN

Resorufin methyl ether have been used as substrate in the incubation mixture, during the determination of cytochrome P4501A activities such as ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-demethylase(MROD) in liver microsomes, using high performance liquid chromatography(HPLC).

The Uses of METHOXYRESORUFIN

Used to differentiate isozymes of cytochrome P-450

What are the applications of Application

Resorufin methyl ether is a fluorometric substrate

Biochem/physiol Actions

Fluorimetric substrate for cytochrome P450 linked enzymes.

Properties of METHOXYRESORUFIN

Melting point: ≥220 °C(lit.)
Boiling point: 378.8±42.0 °C(Predicted)
Density  1.33±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMF: soluble
pka 1.42±0.20(Predicted)
form  Powder
color  Brown to reddish brown
BRN  209529

Safety information for METHOXYRESORUFIN

Computed Descriptors for METHOXYRESORUFIN

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