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HomeProduct name listMETHACHOLINE CHLORIDE

METHACHOLINE CHLORIDE

Synonym(s):(2-Acetoxypropyl)trimethylammonium chloride;Acetyl-β-methylcholine chloride;Methacholine chloride

  • CAS NO.:62-51-1
  • Empirical Formula: C8H18ClNO2
  • Molecular Weight: 195.69
  • MDL number: MFCD00011817
  • EINECS: 200-537-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 20:01:59
METHACHOLINE CHLORIDE Structural

What is METHACHOLINE CHLORIDE?

Chemical properties

colourless to white crystalline powder with a slight

The Uses of METHACHOLINE CHLORIDE

antihypertensive, antianginal

The Uses of METHACHOLINE CHLORIDE

Acetyl-β-methylcholine (methacholine), an analog of acetylcholine, is use as a receptor agonist to study processes such as airway hyperresponsiveness associated with asthma.

What are the applications of Application

Acetyl-β-methylcholine chloride is a metabolically stable analog of acetylcholine

Definition

ChEBI: Methacholine chloride is a quaternary ammonium salt. It contains a methacholine.

General Description

Methacholine chloride occurs as colorless or white crystalsor as a white crystalline powder. It is odorless or has aslight odor and is very deliquescent. It is freely soluble inwater, alcohol, or chloroform, and its aqueous solution isneutral to litmus and bitter. It is hydrolyzed rapidly in alkalinesolutions. Solutions are relatively stable to heat and willkeep for at least 2 or 3 weeks when refrigerated to delaygrowth of molds.

Biochem/physiol Actions

Metabolically stable analog of acetylcholine; muscarinic agonist. Its ability to constrict airway smooth muscle is used to assess bronchial reactivity in the laboratory and clinically.

Clinical Use

Methacholine, acetyl β-methylcholine, is marketed as the racemic mixture. It is a selective muscarinic agonist with very little activity at nicotinic receptors. Although methacholine chloride is marketed as the racemic mixture, the S-(+)-enantiomer is 240-fold more potent than the R-(–)-isomer at muscarinic receptors. In addition, AChE hydrolyzes S-(+)–methacholine at approximately 54% the rate of acetylcholine, whereas the R-(–)–enantiomer is a weak inhibitor. Methacholine chloride is used via inhalation for the diagnosis of asthma. The resulting bronchospasm may be relieved with bronchodilators. Methacholine chloride is available as a powder that is reconstituted for inhalation.

Purification Methods

It forms white hygroscopic needles from Et2O and is soluble in H2O, EtOH and CHCl3. It decomposes readily in alkaline solutions and slowly in H2O. It should be handled and stored in a dry atmosphere. The bromide is less hygroscopic, and the picrate has m 129.5-131o (from EtOH). [racemate: Annis & Ely Biochem J 53 34 1953, IR of iodide: Hansen Acta Chem Scand 13 155 1959, Beilstein 4 IV 1670.]

Properties of METHACHOLINE CHLORIDE

Melting point: 171-173 °C(lit.)
Density  1.1028 (rough estimate)
refractive index  1.5790 (estimate)
storage temp.  -20°C
solubility  H2O: 50 mg/mL, clear, colorless
form  powder
color  White to Almost white
PH 3.0~7.0 (50g/l, 25℃)
Water Solubility  almost transparency
Merck  14,5940
BRN  4162373
Stability: Unstable - moisture sensitive. Incompatible with oxidizing agents.
CAS DataBase Reference 62-51-1
EPA Substance Registry System 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (62-51-1)

Safety information for METHACHOLINE CHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for METHACHOLINE CHLORIDE

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