MYRISTOYL-DL-CARNITINE CHLORIDE
- CAS NO.:14919-38-1
- Empirical Formula: C21H42ClNO4
- Molecular Weight: 408.02
- MDL number: MFCD00063479
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is MYRISTOYL-DL-CARNITINE CHLORIDE?
The Uses of MYRISTOYL-DL-CARNITINE CHLORIDE
(+/-)-Myristoylcarnitine Chloride is a homolog of Acetylcarnitine Chloride (A171990), and an intermediate in lipid metabolism.
What are the applications of Application
(±)-Myristoylcarnitine chloride is a homolog of acetylcarnitine chloride, and an intermediate in lipid metabolism
Biological Activity
(±)-myristoylcarnitine chloride is an agonist for cholinergic and a homolog of acetylcarnitine chloride (cat no. b6273).acetylcholine receptor (achr) is an integral membrane protein receptor for acetylcholine. there are two kinds of achrs: nicotinic acetylcholine receptors and muscarinic acetylcholine receptors.(±)-myristoylcarnitine chloride is a cholinergic agonist and an intermediate in lipid metabolism [1]. in retinal ganglion cells, acetylcarnitine and acetylcholine inhibited gabaergic responses to exogenous gaba and gabaergic inhibitory postsynaptic currents [2].in dogs with coronary ligation, (-)-carnitine chloride (lcc) (300 mg/kg) and acetyl (-)-carnitine chloride (alcc) (300 mg/kg) inhibited the ventricular arrhythmia. also, lcc and alcc improved oxidative phosphorylation rate and the mitochondrial function [1]. in the mouse hot plate test, acetyl-l-carnitine (alcar) (100 mg/kg) exhibited analgesia. while, u-73122 and neomycin (the phospholipase c (plc) inhibitors) blocked the increase of the pain threshold induced by alcar. licl that impairing phosphatidylinositol synthesis antagonized the antinociception in a dose-dependent way. pma and pdbu (pkc activators) blocked the increase of the pain threshold in a dose-dependent way. these results suggested that alcar analgesia required the participation of the plc-ip3 pathway [3].
Properties of MYRISTOYL-DL-CARNITINE CHLORIDE
storage temp. | −20°C |
solubility | <10.2mg/ml in H2O |
form | solid |
color | White |
Water Solubility | Soluble to 25 mM in water |
Safety information for MYRISTOYL-DL-CARNITINE CHLORIDE
Computed Descriptors for MYRISTOYL-DL-CARNITINE CHLORIDE
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