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HomeProduct name listMepivacaine hydrochloride

Mepivacaine hydrochloride

Synonym(s):1-Methyl-2′,6′-pipecoloxylidine hydrochloride;1-Methyl-2,6-pipecoloxylidine hydrochloride;Carbocaine hydrochloride;Mepivacaine hydrochloride;N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride

  • CAS NO.:1722-62-9
  • Empirical Formula: C15H22N2O.ClH
  • Molecular Weight: 282.81
  • MDL number: MFCD00144738
  • EINECS: 217-023-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-07 21:39:59
Mepivacaine hydrochloride Structural

What is Mepivacaine hydrochloride?

Chemical properties

White Solid

The Uses of Mepivacaine hydrochloride

Mepivacaine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.

The Uses of Mepivacaine hydrochloride

An anti-inflammatory and analgesic

Definition

ChEBI: The hydrochloride salt of mepivacaine. It is used as a local anaesthetic.

brand name

Arestocaine Hydrochloride (Solvay Pharmaceuticals); Carbocaine (Hospira); Isocaine Hydrochloride(Novocol); Polocaine (AstraZeneca); Polocaine (Dentsply); Scandonest (Deproco).

Biological Functions

Mepivacaine hydrochloride (Carbocaine) is longer acting than lidocaine and has a more rapid onset of action (3–5 minutes). Topical application is not effective. It has been widely used in obstetrics, but its use has declined recently because of the early transient neurobehavioral effects it produces. Adverse reactions associated with mepivacaine are generally similar to those produced by other local anesthetics. It can be used with epinephrine or levonordefrin (dental use only).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Mepivacaine hydrochloride is a local anesthetic that is related chemically and pharmacologically to the amide-type local anesthetics. It is often administered via local infiltration, peripheral nerve block, etc.

Biochem/physiol Actions

Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.

Safety Profile

skin irritant. Questionable carcinogen with

Mechanism of action

Mepivacaine hydrochloride acts by binding to specific membrane sodium ion channels in the neuronal cell membranes, thereby inhibiting sodium influx. This leads to a blockage of nerve impulse conduction and results in a loss of sensation.

Properties of Mepivacaine hydrochloride

Melting point: 255-257°C (dec.)
storage temp.  2-8°C
solubility  H2O: soluble20mg/mL, clear
form  powder
color  white to beige
InChI InChI=1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H
CAS DataBase Reference 1722-62-9(CAS DataBase Reference)
EPA Substance Registry System 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (1722-62-9)

Safety information for Mepivacaine hydrochloride

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
H336:Specific target organ toxicity,single exposure; Narcotic effects
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P271:Use only outdoors or in a well-ventilated area.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for Mepivacaine hydrochloride

InChIKey RETIMRUQNCDCQB-UHFFFAOYSA-N
SMILES C1(=C(C)C=CC=C1C)NC(=O)C1CCCCN1C.Cl

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