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HomeProduct name listBenidipine hydrochloride

Benidipine hydrochloride

Synonym(s):(4R)-rel-3,5-Pyridinedicarboxylic acid;1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-;3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester;hydrochloride (1:1);KW-3049

  • CAS NO.:91599-74-5
  • Empirical Formula: C28H31N3O6.HCl
  • Molecular Weight: 542.02
  • MDL number: MFCD00906929
  • EINECS: 663-500-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
Benidipine hydrochloride Structural

What is Benidipine hydrochloride?

Description

Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals, benidipine hydrochloride dose dependently induced hypotension with a potency of 6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a slow onset of action.

Description

Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels. In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology. It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury. Benidipine is also a competitive antagonist at mineralocorticoid receptors.

Chemical properties

Yellow Crystalline Powder

Originator

Kyowa Hakko (Japan)

The Uses of Benidipine hydrochloride

A dihydropyridine calcium channel blocker. Antihypertensive.

What are the applications of Application

Benidipine Hydrochloride is a calcium channel protein inhibitor

brand name

Coniel

Biological Activity

Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.

Safety Profile

A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl.

storage

room temperature (desiccate)

Properties of Benidipine hydrochloride

Melting point: 199-201°C
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  DMSO: ≥20mg/mL
form  powder
pka 7.34(at 25℃)
color  yellow
CAS DataBase Reference 91599-74-5(CAS DataBase Reference)

Safety information for Benidipine hydrochloride

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for Benidipine hydrochloride

InChIKey DGVVISBYHUXFIU-UHFFFAOYSA-N

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