Benidipine hydrochloride
Synonym(s):(4R)-rel-3,5-Pyridinedicarboxylic acid;1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-;3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester;hydrochloride (1:1);KW-3049
- CAS NO.:91599-74-5
- Empirical Formula: C28H31N3O6.HCl
- Molecular Weight: 542.02
- MDL number: MFCD00906929
- EINECS: 663-500-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Benidipine hydrochloride?
Description
Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals, benidipine hydrochloride dose dependently induced hypotension with a potency of 6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a slow onset of action.
Description
Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels. In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology. It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury. Benidipine is also a competitive antagonist at mineralocorticoid receptors.
Chemical properties
Yellow Crystalline Powder
Originator
Kyowa Hakko (Japan)
The Uses of Benidipine hydrochloride
A dihydropyridine calcium channel blocker. Antihypertensive.
What are the applications of Application
Benidipine Hydrochloride is a calcium channel protein inhibitor
brand name
Coniel
Biological Activity
Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.
Safety Profile
A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl.
storage
room temperature (desiccate)
Properties of Benidipine hydrochloride
Melting point: | 199-201°C |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO: ≥20mg/mL |
form | powder |
pka | 7.34(at 25℃) |
color | yellow |
CAS DataBase Reference | 91599-74-5(CAS DataBase Reference) |
Safety information for Benidipine hydrochloride
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for Benidipine hydrochloride
InChIKey | DGVVISBYHUXFIU-UHFFFAOYSA-N |
Abamectin manufacturer
Prayosha Health Care Pvt Ltd
Ralington Pharma
Globela Industry Pvt Ltd
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